31872-64-7

Basic information

• Product Name: 3-Chloro-4-hydroxy-5-nitropyridine
• Synonyms: 3-Chloro-4-hydroxy-5-nitropyridine;3-Chloro-5-nitro-4-pyridinol;5-Chloro-3-nitro-4-pyridinol
• CAS NO: 31872-64-7
• Molecular Formula: C₅H₃ClN₂O₃
• Molecular Weight: 174.54
• Mol File: 31872-64-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 263℃
• Boiling Point: 339.3±37.0 °C(Predicted)
• Appearance: /
• Density: 1.664±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: -1.56±0.38(Predicted)
• CAS DataBase Reference: 3-Chloro-4-hydroxy-5-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-4-hydroxy-5-nitropyridine(31872-64-7)
• EPA Substance Registry System: 3-Chloro-4-hydroxy-5-nitropyridine(31872-64-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 31872-64-7(Hazardous Substances Data)

Usage

General Description

3-Chloro-4-hydroxy-5-nitropyridine is a chemical compound with the molecular formula C5H3ClN2O3. It is a pale yellow crystalline solid that is primarily used as an intermediate in the production of pharmaceuticals and agrochemicals. The compound is also known for its electrophilic substitution reactions, making it a valuable building block in organic synthesis. 3-Chloro-4-hydroxy-5-nitropyridine has the potential to exhibit both anti-inflammatory and antibacterial properties, making it a promising candidate for further research and development in the medical and agricultural industries. It is important to handle and store this compound with caution, as it may pose health and environmental risks if not properly managed.

InChI:InChI=1S/C5H3ClN2O3/c6-3-1-7-2-4(5(3)9)8(10)11/h1-2H,(H,7,9)

Upstream product

• 5435-54-1 4-hydroxy-3-nitropyridine 

Downstream Products

• 1186084-29-6 4-chloro-N-({1-[(3S)-3-methylpiperazin-1-yl]cyclohexyl}methyl)-1-pyrimidin-2-yl-1H-pyrrolo[2,3-c]pyridine-3-carboxamide 
• 56809-84-8 3,4-dichloro-5-nitropyridine 

Relevant articles and documents

4 - SUBSTITUTED 1, 3 - DIHYDRO - 2H - BENZIMIDAZOL - 2 - ONE DERIVATIVES SUBSTITUTED WITH BENZIMIDAZOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS

The present invention is concerned with novel 4-substituted 1,3-dihydro-2H- benzimidazol-2-one derivatives substituted with benzimidazoles having formula (I), tautomers and stereoisomeric forms thereof, and the pharmaceutically acceptable addition salts, and the solvates thereof, wherein R4, R5, Z and Het have the meaning defined in the claims. The compounds according to the present invention are useful as inhibitors on the replication of the respiratory syncytial virus (RSV). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use in the treatment of respiratory syncytial virus infection.

HETEROARYL AMIDE ANALOGUES

Compounds, pharmaceutical compositions, and methods of use are disclosed for heteroaryl amide analogues of formula Ia and/or Ib. In certain embodiments, the heteroaryl amide analogues are agonists and/or ligands of dopamine receptors and may be useful, inter alia, for the treatment of a condition responsive to P2X7 receptor modulation, for example, pain, inflammation, a neurological or neurodegenerative disorder, a cardiovascular disorder, an ocular disorder or an immune system disorder.