318988-54-4

Basic information

• Product Name: 1,4-diaza-4-(benzyloxycarbonyl)-7-oxaspiro[bicyclo[4.3.0]nonane-8,4'-piperidin]-2-one
• Synonyms: 1,4-diaza-4-(benzyloxycarbonyl)-7-oxaspiro[bicyclo[4.3.0]nonane-8,4'-piperidin]-2-one
• CAS NO: 318988-54-4
• Molecular Weight: 345.398
• Mol File: 318988-54-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,4-diaza-4-(benzyloxycarbonyl)-7-oxaspiro[bicyclo[4.3.0]nonane-8,4'-piperidin]-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-diaza-4-(benzyloxycarbonyl)-7-oxaspiro[bicyclo[4.3.0]nonane-8,4'-piperidin]-2-one(318988-54-4)
• EPA Substance Registry System: 1,4-diaza-4-(benzyloxycarbonyl)-7-oxaspiro[bicyclo[4.3.0]nonane-8,4'-piperidin]-2-one(318988-54-4)

Safety Data

• Hazardous Substances Data: 318988-54-4(Hazardous Substances Data)

Upstream product

• 318988-50-0 N-(2,2-diethoxyethyl)-N-[(phenylmethoxy)carbonyl]glycine ethyl ester 
• 501-53-1 benzyl chloroformate 
• 318988-51-1 N-(2-oxoethyl)-N-[(phenylmethoxy)carbonyl]glycine ethyl ester 
• 318988-53-3 tetrahydro-5-oxo-1'-(phenylmethyl)spiro[7H-oxazolo[3,2-a]pyrazine-2(3H),4'-piperidine]-7-carboxylic acid phenylmethyl ester 

Downstream Products

• 318988-55-5 tetrahydro-5-oxo-1'-(4-pyridinyl)spiro[7H-oxazolo[3,2-a]pyrazine-2(3H),4'-piperidine]-7-carboxylic acid phenylmethyl ester 

Relevant articles and documents

Synthesis and evaluation of 1-arylsulfonyl-3-piperazinone derivatives as factor Xa inhibitors1-4 V. A series of new derivatives containing a spiro[imidazo[1,2-a]pyrazine-2(3H),4′-piperidin]-5(1H)-one scaffold

We have already reported unique compounds containing a N,O-spiro acetal structure as an orally active factor Xa (FXa) inhibitor. This time, we described a N,N-spiro acetal structure as an analogue of the N,O-spiro acetal structure for an orally active FXa

TRICYCLIC COMPOUNDS HAVING SPIRO UNION

This invention relates to tricyclic compounds having spiro union represented by the following formula (I) or its salt which is useful as a drug, and in particular, as an inhibitor for activated blood coagulation factor X, which can be administered orally