319442-16-5

Basic information

• Product Name: Thieno[3,2-d]pyrimidine, 4-chloro-2-methyl-
• Synonyms: Thieno[3,2-d]pyrimidine, 4-chloro-2-methyl-
• CAS NO: 319442-16-5
• Molecular Formula: C₇H₅ClN₂S
• Molecular Weight: 184.646
• EINECS: 200-589-5
• Mol File: 319442-16-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 208℃
• Flash Point: 80℃
• Appearance: /
• Density: 1.445
• Refractive Index: 1.682
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.99±0.40(Predicted)
• CAS DataBase Reference: Thieno[3,2-d]pyrimidine, 4-chloro-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Thieno[3,2-d]pyrimidine, 4-chloro-2-methyl-(319442-16-5)
• EPA Substance Registry System: Thieno[3,2-d]pyrimidine, 4-chloro-2-methyl-(319442-16-5)

Safety Data

• Hazard Codes: T
• Statements: 25-36
• Safety Statements: 26-45
• WGK Germany: 3
• Hazardous Substances Data: 319442-16-5(Hazardous Substances Data)

Usage

General Description

Thieno[3,2-d]pyrimidine, 4-chloro-2-methyl- is a chemical compound with the molecular formula C8H6ClN3S. It is a member of the thienopyrimidine family and features a thieno ring fused to a pyrimidine ring, with a chlorine atom and a methyl group attached at specific positions. Thieno[3,2-d]pyrimidine, 4-chloro-2-methyl- is used in the pharmaceutical industry as a building block for the synthesis of various drugs and bioactive molecules. It is also studied for its potential pharmacological properties, including anti-cancer and anti-inflammatory activities. Thieno[3,2-d]pyrimidine, 4-chloro-2-methyl- is a versatile compound that has applications in medicinal chemistry and drug discovery.

InChI:InChI=1/C7H5ClN2S/c1-4-9-5-2-3-11-6(5)7(8)10-4/h2-3H,1H3

Upstream product

• 22288-78-4 Methyl 3-aminothiophene-2-carboxylate 
• 22288-79-5 3-acetylamine-2-thiophenecarboxylic acid methyl ester 
• 18678-13-2 2-methyl-3H-thieno[3,2-d]pyrimidin-4-one 
• 1037297-94-1 3-acetamidothiophene-2-carboxamide 
• 147123-47-5 3-aminothiophene-2-carboxamide 
• 1611471-26-1 ethyl 3-amino-2-thiophene-2-carboxylate hydrochloride 
• 18678-13-2 2-methylthieno[3,2-d]pyrimidin-4-ol 

Downstream Products

• 936837-05-7 N-(4-methoxyphenyl)-N,2-dimethylthieno[3,2-d]pyrimidin-4-amine 
• 935843-00-8 N-(2,5-dimethoxyphenyl)-2-methylthieno[3,2-d]pyrimidin-4-amine 

Relevant articles and documents

Thienopyrimidine derivative as an active ingredient a plant disease control agent (by machine translation)

[Problem] in plant disease resistance-inducing gene expression found thienopyrimidine derivative effect, utilizing the thienopyrimidine derivatives, injuries to plant disease organisms[Solution] some of the thienopyrimidine derivatives, such as gene expression in a plant disease-resistance gene to induce PR-a 1, therefore cruciferous vegetables against plant diseases caused by pathogenic bacillus anthracis, exhibiting excellent control effect was found. [Drawing] no (by machine translation)

Discovery of new hit-molecules targeting Plasmodium falciparum through a global SAR study of the 4-substituted-2-trichloromethylquinazoline antiplasmodial scaffold

From 4 antiplasmodial hit-molecules identified in 2-trichloromethylquinazoline series, we conducted a global Structure-Activity relationship (SAR) study involving 26 compounds and covering 5 molecular regions (I – V), aiming at defining the corresponding

THIENO[3,2-D]PYRIMIDINE-6-CARBOXAMIDES AND ANALOGUES AS SIRTUIN MODULATORS

Provided herein are novel substituted thieno[3,2-d]pyrimidine-6-carboxamide sirtuin inhibitors and methods of use thereof. The sirtuin inhibitors may be used for inhibiting a sirtuin-mediated biological process, and, e.g. for treating and/or preventing diseases and disorders including, but not limited to cancer, neurodegenerative disease and inflammation. Also provided herein are pharmaceutical compositions comprising these sirtuin inhibitors and compositions comprising a sirtuin inhibitor in combination with another therapeutic agent.