319493-07-7

Basic information

• Product Name: 1H-Indole, 6-bromo-3-(2-nitroethenyl)-
• Synonyms: 6-bromo-3-(2-nitroethenyl)-indole
• CAS NO: 319493-07-7
• Molecular Formula: C10H7BrN2O2
• Molecular Weight: 267.082
• Mol File: 319493-07-7.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 6-bromo-3-(2-nitroethenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 6-bromo-3-(2-nitroethenyl)-(319493-07-7)
• EPA Substance Registry System: 1H-Indole, 6-bromo-3-(2-nitroethenyl)-(319493-07-7)

Safety Data

• Hazardous Substances Data: 319493-07-7(Hazardous Substances Data)

Usage

Structure

A derivative of indole with a bromine atom and a nitroethenyl group attached

Usage

Commonly used in the synthesis of various organic compounds and pharmaceuticals

Applications

Potential applications in medicinal chemistry, drug development, and research and development of new materials and chemicals.

Upstream product

• 120-72-9 indole 
• 496-15-1 1-indoline 
• 119-32-4 4-Methyl-3-nitroanilin 
• 78508-22-2 β-dimethylamino-2-nitrostyrene 
• 60956-26-5 4-bromo-2-nitrotoluene 
• 17826-04-9 6-bromo-1H-indole-3-carbaldehyde 
• 75-52-5 nitromethane 
• 52415-29-9 6-bromo-1H-indole 
• 73430-27-0 1-dimethylamino-2-nitroethene 

Downstream Products

• 1242146-13-9 eudistomidin G 
• 1384331-17-2 C₃₅H₃₂BrN₃O₃ 
• 1384331-16-1 C₃₅H₃₀BrN₃O₂ 
• 1384331-18-3 C₃₅H₃₂BrN₃O₂ 
• 1384331-19-4 C₃₆H₃₄BrN₃O₂ 
• 1384331-21-8 C₃₇H₃₆BrN₃O₃ 
• 1318767-44-0 eudistomidin H 
• 1631136-29-2 C₂₈H₂₉BrN₂O 
• 61-54-1 tryptamine 
• 96624-18-9 6-bromotryptamine 

Relevant articles and documents

First total synthesis of eudistalbin A

Eudistalbin A was isolated from marine tunicate eudistoma album and possess cytotoxic activity (ED50 50 value of 2.1 μmol/L using the metabolic assay MTT. All structures of new compounds were confirmed by 1H NMR, 13C NMR, HRMS and optical rotation.

Metal-Free Dearomatization: Direct Access to Spiroindol(en)ines in Batch and Continuous-Flow

A metal-free, phosphine-catalyzed intramolecular “umpolung Michael addition” on alkynes to form spiroindol(en)ines is reported. This nucleophilic catalysis enables the formation of a wide scope of five- and six-membered spiroindol(en)ines in moderate to excellent yields in batch as well as under continuous-flow conditions. Triphenylphosphine-catalyzed nucleophilic activation of alkynes allows the exclusive formation of exo-product under mild reaction conditions.

An environmentally friendly protocol for oxidative halocyclization of tryptamine and tryptophol derivatives

An environmentally friendly and efficient protocol (KX/oxone) for oxidative halocyclization of tryptamine/tryptophol derivatives was developed and demonstrated with 28 examples and concise total synthesis of cyclotryptamine alkaloid protubonines A and B. The distinct advantage of this protocol over all previous methods is that no organic byproduct is generated from a halogenating agent or oxidant, thus greatly reducing the environmental impact of halocyclization and facilitating the post-reaction purification.