31951-33-4

Basic information

• Product Name: 3-METHYL-INDOLE-1-CARBALDEHYDE
• Synonyms: 3-METHYL-INDOLE-1-CARBALDEHYDE;1H-Indole-1-carboxaldehyde, 3-methyl- (9CI)
• CAS NO: 31951-33-4
• Molecular Formula: C₁₀H₉NO
• Molecular Weight: 159.18456
• Product Categories: ALDEHYDE
• Mol File: 31951-33-4.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 311.139°C at 760 mmHg
• Flash Point: 141.972°C
• Appearance: /
• Density: 1.108g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.585
• CAS DataBase Reference: 3-METHYL-INDOLE-1-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYL-INDOLE-1-CARBALDEHYDE(31951-33-4)
• EPA Substance Registry System: 3-METHYL-INDOLE-1-CARBALDEHYDE(31951-33-4)

Safety Data

• Hazardous Substances Data: 31951-33-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H9NO/c1-8-6-11(7-12)10-5-3-2-4-9(8)10/h2-7H,1H3

Upstream product

• 83-34-1 3-Methylindole 
• 1478-41-7 diethoxycarbonium fluoroborate 
• 68-12-2 N,N-dimethyl-formamide 
• 64-18-6 formic acid 

Downstream Products

• 83836-39-9 N-[1-(3-Methyl-indol-1-yl)-meth-(E)-ylidene]-N'-(4-nitro-phenyl)-hydrazine 
• 89725-80-4 3-Methyl-indole-1-carbaldehyde oxime 

Relevant articles and documents

Open-chain analogs of LSD. II. Synthesis of some 2-(3-indolylethyl)- and 2-(3-methyl-2-indolylethyl)piperidines.

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Nano rod-shaped and reusable basic Al2O3 catalyst for N-formylation of amines under solvent-free conditions: A novel, practical and convenient 'NOSE' approach

An expeditious, simple, highly efficient, practical and green protocol for the N-formylation of alkyl/aryl amines and indole derivatives catalyzed by novel nano rod-shaped basic Al2O3 under solvent-free conditions has been developed. The catalyst is efficiently recycled up to the 5th run, an important point in the domain of green chemistry. The methodology provides cleaner conversion, shorter reaction times and high selectivity which makes the protocol attractive. The Royal Society of Chemistry 2012.

Neat formic acid: An excellent N-formylating agent for carbazoles, 3- alkylindoles, diphenylamine and moderately weak nucleophilic anilines

Neat formic acid alone efficiently N-formylates carbazoles, 3- alkylindoles, diphenylamine and even moderately weak nucleophilic anilines to furnish the corresponding N-formyl derivatives in 72-87% yields.