319914-08-4Relevant articles and documents
Method for preparing medical intermediate 4-hydroxy-3-methoxyphenylacetone
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Paragraph 0021-0060, (2018/06/15)
The invention discloses a method for preparing a medical intermediate 4-hydroxy-3-methoxyphenylacetone. The method comprises steps as follows: firstly, a catalyst containing graphene, zirconia and Ptis prepared, 2-methoxy-4-(2-nitro-1-allyl) phenol is prepared from vanillic aldehyde and nitroethane as raw materials under the catalysis of glacial acetic acid and n-butylamine, and 2-methoxy-4-(2-oximido propyl) phenol is prepared from 2-methoxy-4-(2-nitro-1-allyl) phenol as a reaction raw material by adding ammonium formate and the self-made catalyst through stirring reaction; finally, 2-methoxy-4-(2-oximido propyl) phenol and a sulfuric acid solution are subjected to the stirring reaction for 1-3 h at the room temperature, after the reaction, a reaction liquid is left to stand for layering, a xylene layer is separated out and dried with anhydrous sodium sulfate, a solvent is removed through reduced-pressure concentration, fractions at 150-151 DEG C are collected, and 4-hydroxy-3-methoxyphenylacetone is obtained. The method is simple to operate, purity of a target product is high, yield is high, and cost is low.
