3201-26-1

Basic information

• Product Name: 1,2,3-Trimethyl-1H-pyrazole-5(2H)-one
• Synonyms: 1,2,3-Trimethyl-1H-pyrazole-5(2H)-one;1,2-Dihydro-1,2,5-trimethyl-3H-pyrazol-3-one
• CAS NO: 3201-26-1
• Molecular Formula: C₆H₁₀N₂O
• Molecular Weight: 126.16
• Mol File: 3201-26-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,2,3-Trimethyl-1H-pyrazole-5(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3-Trimethyl-1H-pyrazole-5(2H)-one(3201-26-1)
• EPA Substance Registry System: 1,2,3-Trimethyl-1H-pyrazole-5(2H)-one(3201-26-1)

Safety Data

• Hazardous Substances Data: 3201-26-1(Hazardous Substances Data)

Usage

Abbreviation

TMAPO

Physical state

Colorless solid

Usage

a. Organic synthesis
b. Reagent in chemical reactions

Industry application

Pharmaceutical industry (as a versatile building block)

Biological activity

Used to synthesize a variety of biologically active compounds

Coordination chemistry

Used as a ligand

Catalyst preparation

Used in the preparation of catalysts for organic reactions

Applications

Wide range of applications due to unique structure and properties

Importance

Considered an important chemical in the field of organic chemistry

Upstream product

• 141-97-9 ethyl acetoacetate 
• 57-14-7 N,N-Dimethylhydrazine 
• 540-73-8 1,2-Dimethylhydrazine 
• 105-45-3 acetoacetic acid methyl ester 
• 74-83-9 methyl bromide 
• 2749-59-9 1,3-dimethyl-5-pyrazolone 
• 73664-86-5 1,2-dimethylhydrazine hydrochloride 
• 77-78-1 dimethyl sulfate 
• 108-26-9 3-methyl-2-pyrazoline-5-one 
• 74-88-4 methyl iodide 
• 3201-28-3 1,5-dimethyl-1,2-dihydro-3-pyrazolone 

Downstream Products

• 66181-69-9 1,2,5-trimethyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carbaldehyde 
• 57-14-7 N,N-Dimethylhydrazine 
• 79138-41-3 1,2,5-trimethyl-4-<(phenylimino)methyl>-1,2-dihydro-3H-pyrazol-3-one 

Relevant articles and documents

Metal-Free Direct C–H Thiolation and Thiocyanation of Pyrazolones

Metal-free approach for direct C–H thiolation and thiocyanation of N-substituted pyrazolones with disulfides and thiocyanate salts, respectively, are developed. These reactions allow the C–S bond coupling to proceed effectively under mild conditions, providing useful and convenient methods for preparation of a series of 4-thio-substituted pyrazolone analogues, which have potential applications in organic, medicinal and material chemistry. Preliminary mechanistic investigation suggested that radical processes are likely to involve in these transformations.

SUBSTITUTED BENZENE COMPOUNDS

The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.