320347-97-5Relevant articles and documents
A PROCESS FOR PREPARING ACLIDINIUM BROMIDE AND INTERMEDIATES THEREOF
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Page/Page column 3; 6; 7; 9; 10; 12; 15, (2018/09/12)
Provided herein is a process for synthesis of aclidinium bromide and intermediates thereof, wherein the process for the preparation of aclidinium bromide increases the % yield of aclidinium bromide by about 70% to 90%.
Preparation method of quinine-3-yl R-2,2-di(2-thienyl)-2-glycolate
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Paragraph 0028-0029, (2018/06/04)
The invention discloses a preparation method of quinine-3-yl R-2,2-di(2-thienyl)-2-glycolate, and belongs to the technical field of preparation and application of an anti-chronic obstructive pulmonarydisease drug aclidinium bromide intermediate. The preparation method comprises the following steps: adding methyl 2,2-dithienylglycolate, R-(-)-3-quinuclidinol and sodium methoxide into an organic solvent in an inert gas atmosphere, and carrying out a heating reaction; and adding the obtained reaction solution into a diluted acid solution after the reaction is finished, separating the obtained water layer, alkalizing the water layer, and filtering the alkalinized water layer to obtain the quinine-3-yl R-2,2-di(2-thienyl)-2-glycolate. The preparation method of the quinine-3-yl R-2,2-di(2-thienyl)-2-glycolate has the advantages of simplicity in operation, high yield, mild conditions, few three wastes, and easiness in industrial production.
High-purity high-yield aclidinium bromide preparation method suitable for industrial production
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Paragraph 0014; 0020; 0025, (2017/07/21)
The invention discloses a high-purity high-yield aclidinium bromide preparation method suitable for industrial production. The preparation method comprises the following steps: 1) adding methyl 2,2-di(2-thienyl)-2-hydroxyacetate and TBDMSCl into solvent,