320363-23-3

Basic information

• Product Name: C₂₂H₂₅Cl₂N₅O₄
• Synonyms: C₂₂H₂₅Cl₂N₅O₄
• CAS NO: 320363-23-3
• Molecular Weight: 494.378
• Mol File: 320363-23-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₅Cl₂N₅O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₅Cl₂N₅O₄(320363-23-3)
• EPA Substance Registry System: C₂₂H₂₅Cl₂N₅O₄(320363-23-3)

Safety Data

• Hazardous Substances Data: 320363-23-3(Hazardous Substances Data)

Upstream product

• 320365-95-5 4-amino-6-methoxy-7-{2-[N-(2-methoxyethyl)-N-methylamino]ethoxy}-quinazoline 
• 39920-37-1 2,6-dichlorophenylisocyanate 

Relevant articles and documents

Therapy

The invention concerns the use of a quinazoline derivative of Formula (I) wherein Q1 includes a quinazoline ring optionally substituted with a group such as halogeno, trifluoromethyl and cyano, or a group of the formula: Q3—X1— wherein X1 includes a direct bond and O and Q3includes aryl, aryl-(1-6C)alkyl, heterocyclyl and heterocyclyl-(1-6C)alkyl; each of R2 and R3 is hydrogen or (1-6C)alkyl; Z includes O, S and NH; and Q2 includes aryl and aryl-(1-3C)alkyl or a pharmaceutically-acceptable salt thereof, in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in a warm-blooded animal such as a human.