32046-03-0Relevant articles and documents
Studies on Pyrazines. 9. The Facile Synthesis of Pyrazine 1-Oxides Substituted at C-2 with Cyano, Methoxycarbonyl and Carboxy Groups
Sato, Nobuhiro
, p. 169 - 171 (2007/10/02)
The peroxysulfuric acid oxidation of 2-cyanopyrazine (1) gave its 1-oxide 3 (18percent yield) and pyrazinecarboxamide (8percent yield), while that of methyl pyrazinecarboxylate (2) provided the 1- and 4-oxides in 15 and 7percent yields, respectively.On the other hand, pyrazinecarboxylic acid 1-oxide (7) was prepared by condensation of 2-methylpyrazine 1-oxide (8) with benzaldehyde followed by oxidative cleavage (47percent overall yield).