32083-66-2

Basic information

• Product Name: (4-FLUOROBENZENESULFONYL)ACETONITRILE
• Synonyms: BUTTPARK 94\04-21;(4-FLUOROBENZENESULFONYL)ACETONITRILE;(4-FLUOROBENZENESULPHONYL)ACETONITRILE;AKOS BBS-00002847;2-[(4-FLUOROPHENYL)SULFONYL]ACETONITRILE;(4-Fluorobenzenesulphonyl)acetonitrile 97%;(4-Fluorobenzenesulphonyl)acetonitrile97%;4-Fluorophenylsulfonylacetonitrile, 97%
• CAS NO: 32083-66-2
• Molecular Formula: C₈H₆FNO₂S
• Molecular Weight: 199.2
• Product Categories: Phenyls & Phenyl-Het
• Mol File: 32083-66-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 87 °C
• Boiling Point: 390.5 °C at 760 mmHg
• Flash Point: 190 °C
• Appearance: white solid
• Density: 1.37 g/cm³
• Vapor Pressure: 2.64E-06mmHg at 25°C
• Refractive Index: 1.529
• CAS DataBase Reference: (4-FLUOROBENZENESULFONYL)ACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: (4-FLUOROBENZENESULFONYL)ACETONITRILE(32083-66-2)
• EPA Substance Registry System: (4-FLUOROBENZENESULFONYL)ACETONITRILE(32083-66-2)

Safety Data

• Hazard Codes: T
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 3276
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 32083-66-2(Hazardous Substances Data)

Usage

Description

(4-FLUOROBENZENESULFONYL)ACETONITRILE, also known as 4-Fluorophenylsulfonylacetonitrile, is an organic compound that serves as a crucial building block in the synthesis of various pharmaceuticals and chemical compounds. It is characterized by its unique chemical structure, which includes a fluorobenzene ring attached to a sulfonyl group and an acetonitrile functional group. This structure endows it with specific reactivity and properties that make it valuable in the chemical and pharmaceutical industries.

Uses

Used in Pharmaceutical Industry:
(4-FLUOROBENZENESULFONYL)ACETONITRILE is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows for the creation of a wide range of molecules with potential therapeutic applications.
Used in Chemical Synthesis:
(4-FLUOROBENZENESULFONYL)ACETONITRILE is used as a chemical intermediate for the production of 3-(4-fluoro-benzenesulfonyl)-thiophen-2-ylamine with [1,4]dithiane-2,5-diol. (4-FLUOROBENZENESULFONYL)ACETONITRILE is an important building block in the synthesis of various organic molecules, including those with potential applications in the pharmaceutical, agrochemical, and materials science industries.

InChI:InChI=1/C8H6FNO2S/c9-7-1-3-8(4-2-7)13(11,12)6-5-10/h1-4H,6H2

Upstream product

• 1624363-23-0 3-azido-2-methylbut-3-en-2-ol 
• 459-45-0 4-fluorobenzenediazonium tetrafluoroborate 
• 352-34-1 4-fluoro-1-iodobenzene 
• 371-42-6 4-Fluorothiophenol 
• 18527-21-4 2-((4-fluorophenyl)thio)acetonitrile 

Downstream Products

• 1276042-81-9 2-(4-fluoro-benzenesulfonyl)-3,3-bis-methylsulfanyl-acrylonitrile 
• 1383563-65-2 [3-(4-fluorobenzenesulfonyl)thieno[2,3-e][1,2,3]triazolo-[1,5-a]pyrimidin-5-yl]thiophen-2-ylmethylamine 
• 1313613-09-0 (E)-2-(4-fluorophenylsulfonyl)-3-(1-(3-nitrophenylsulfonyl)-1H-pyrrol-2-yl)acrylonitrile 
• 1313613-08-9 (E)-3-(2-(2-cyano-2-(4-fluorophenylsulfonyl)vinyl)-1H-pyrrol-1-ylsulfonyl)benzonitrile 
• 1313613-06-7 (E)-2-(4-fluorophenylsulfonyl)-3-(1-(phenylsulfonyl)-1H-pyrrol-2-yl)acrylonitrile 
• 1313612-96-2 (E)-2-((4-fluorophenyl)sulfonyl)-3-(1H-pyrrol-2-yl)acrylonitrile 
• 1313429-71-8 2-amino-1-(2-bromobenzyl)-3-(4-fluorophenylsulfonyl)-4,5-dimethylpyrrole 
• 432-99-5 2-[(4-fluorophenyl)sulfonyl]-1-phenylethan-1-one 
• 1174392-07-4 C₁₅H₉FN₄O₃S 
• 186404-84-2 (E)-3-(2-aminocarbonylthien-5-yl)-2-[(4-fluorobenzene)sulfonyl]acrylonitrile 
• 186404-81-9 (E)-2-[(4-fluorobenzene)sulfonyl]-3-(2-nitrothien-5-yl)acrylonitrile 
• 360071-46-1 3-(4-fluoro-benzenesulfonyl)-thiophen-2-ylamine 

Relevant articles and documents

A Concise Route to 2-Sulfonylacetonitriles from Sodium Metabisulfite

A three-component reaction of aryldiazonium tetrafluoroborates, sodium metabisulfite, and 3-azido-2-methylbut-3-en-2-ol under mild conditions is described. By using abundant and cheap sodium metabisulfite as the sulfur dioxide surrogate, this protocol features good functional group compatibility, affording 2-arylsulfonylacetonitriles in moderate to good yields. The reaction proceeds smoothly at room temperature without the need of any catalysts or additives. Moreover, the synthetic utility of this method is demonstrated by the transformation of 2-arylsulfonylacetonitrile into 2-arylsulfonyl acetamide and 2-arylsulfonylethylamine. (Figure presented.).

TRIAZOLOTHIENOPYRIMIDINE COMPOUND INHIBITORS OF UREA TRANSPORTERS AND METHODS OF USING INHIBITORS

Provided herein are small molecule triazolothienopyrimidine compounds that inhibit urea transport activity of solute transporters, particularly the UT-B transporter. The compounds described herein are useful for increasing solute clearance in states of fluid overload and for treating refractory edema associated with cardiovascular, renal, and metabolic diseases, disorders, and conditions.

Rhodium(I)-catalyzed addition of arylboronic acids to (benzyl-/ arylsulfonyl)acetonitriles: Efficient synthesis of (Z)-β- sulfonylvinylamines and β-Keto sulfones

An efficient rhodium(I)-catalyzed addition of arylboronic acids to (benzyl-/arylsulfonyl)acetonitrile is described. Novel β-sulfonylvinylamine products are formed in a stereoselective fashion (Z-alkene). Upon hydrolysis, useful β-keto sulfones are obtained with a broad scope of aryl and sulfonyl substituents.