3211-76-5 Usage
Description
L-(+)-Selenomethionine, also known as Seleno-L-Methionine (SeMet), is an organic form of selenium found in Cupriavidus metallidurans. It is the L-enantiomer of selenomethionine and exists as a solid with unique chemical properties. L-(+)-Selenomethionine has been shown to increase the expression of glutathione peroxidase, which is an essential antioxidant enzyme in the body.
Uses
Used in Antioxidant Applications:
L-(+)-Selenomethionine is used as an antioxidant agent for its ability to increase the expression of glutathione peroxidase, which helps protect cells from oxidative stress and damage.
Used in Toxicity Studies:
L-(+)-Selenomethionine is used as a research compound in toxicity studies, such as those conducted on Japanese Medaka embryos, to understand its effects on various biological systems and potential environmental impacts.
Used in Selenium Status Studies:
L-(+)-Selenomethionine is used as a research compound in studies examining selenium status indicators, such as those conducted on pregnant long-tailed macaques (Macaca Fascicularis), to better understand the role of selenium in health and nutrition.
Used in Protein Labeling for Crystallography:
L-(+)-Selenomethionine is used as a protein labeling agent for single wavelength anomalous dispersion (SAD) phasing in crystallography. This application allows researchers to determine the three-dimensional structure of proteins, which is crucial for understanding their function and potential therapeutic applications.
Used in Pharmaceutical Industry:
L-(+)-Selenomethionine is used as an active pharmaceutical ingredient for the development of drugs targeting various health conditions, leveraging its antioxidant and selenium-related properties.
Used in Nutritional Supplements:
L-(+)-Selenomethionine is used as an ingredient in nutritional supplements to provide the essential trace element selenium, which is important for maintaining proper immune function, thyroid hormone metabolism, and DNA synthesis.
Biochem/physiol Actions
Seleno-L-Methionine (SeMet) is capable of repressing atopic dermatitis (AD)-like skin lesions. It can also prevent the expression of total immunoglobulin E (IgE) and interleukin 4 (IL-4). It can cause ecotoxicity as it is absorbed by fish through diet.
Check Digit Verification of cas no
The CAS Registry Mumber 3211-76-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,2,1 and 1 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 3211-76:
(6*3)+(5*2)+(4*1)+(3*1)+(2*7)+(1*6)=55
55 % 10 = 5
So 3211-76-5 is a valid CAS Registry Number.
InChI:InChI=1/C5H11NO2Se/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
3211-76-5Relevant articles and documents
A new efficient synthesis of acetyltelluro- and acetylselenomethionine and their use in the biosynthesis of heavy-atom protein analogs
Karnbrock, Wilhelm,Weyher, Elisabeth,Budisa, Nediljko,Huber, Robert,Moroder, Luis
, p. 913 - 914 (1996)
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Synthetic method of L-selenomethionine
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Paragraph 0026-0039, (2020/02/17)
The invention discloses a synthetic method of L-selenomethionine, and belongs to the field of additives. The synthetic method comprises the following steps: A, a compound 1 and a compound 2 react in asolvent, and filtering and drying are carried out after a reaction is completed, and then a green solid compound 3 is obtained; and B, the compound 3 and sodium borohydride react in a protonic solvent for 1-10 h, after a reaction is completed, dimethyl sulfate is dropwise added to continue to react for 1-5 h, then quenching through acetic acid and filtering are conducted, and thus the L-selenomethionine is prepared. The synthetic method has the beneficial effects that 1, it is reported in the literature that the compound 1 is mild in condition and high in yield; 2, the compound 2 is mild in reaction condition, no highly toxic and foul sodium methyl selenide is generated, and labor protection and environmental protection are facilitated; 3, the compound 2 is easy to separate only through centrifugal spinning-filtration, and an obtained product is high in purity; and 4, adopted raw materials and reagents are all commercially available, in the preparation process of the L-selenomethionine, intermediates do not need to be separated, and operation is easy.
Method for synthesizing L L-(+)-selenomethionine (by machine translation)
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Paragraph 0041; 0050-0052; 0058-0062; 0069-0071; 0078-0080, (2019/12/25)
The synthetic route disclosed L - (+) - by the invention has, L - (+) - the advantages that the raw materials, are easy to obtain, the reaction conditions are, mild, the reaction conditions are mild, the separation, and purification are easy, L - (+) - and the; method L - (+) - is easy, to separate and purify L - (+) - L - (+) - L - (+) . (by machine translation)
