32137-20-5

Basic information

• Product Name: 4-CHLORO-3-FLUOROBENZOTRIFLUORIDE
• Synonyms: 4-CHLORO-3-FLUOROOBENZOTRIFLUORIDE;4-CHLORO-3-FLUOROBENZOTRIFLUORIDE;1-CHLORO-2-FLUORO-4-TRIFLUOROMETHYL-BENZENE;4-Chloro-3-fluorobenzotrifluoride 99%;4-Chloro-3-fluorobenzotrifluoride99%;3-FLUORO-4-CHLOROBENZOTRIFLUORIDE
• CAS NO: 32137-20-5
• Molecular Formula: C₇H₃ClF₄
• Molecular Weight: 198.55
• Mol File: 32137-20-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 135 °C
• Flash Point: 47.6°C
• Appearance: /
• Density: 1.427g/cm³
• Refractive Index: 1.44
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-CHLORO-3-FLUOROBENZOTRIFLUORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-3-FLUOROBENZOTRIFLUORIDE(32137-20-5)
• EPA Substance Registry System: 4-CHLORO-3-FLUOROBENZOTRIFLUORIDE(32137-20-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36/37/39-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 32137-20-5(Hazardous Substances Data)

Usage

General Description

4-CHLORO-3-FLUOROBENZOTRIFLUORIDE is an organic compound with the chemical formula C7H3ClF4. It is a colorless liquid that is insoluble in water but soluble in organic solvents. The compound is used as an intermediate in the production of pharmaceuticals, agrochemicals, and other fine chemicals. It is also used as a reagent in the synthesis of various organic compounds. 4-CHLORO-3-FLUOROBENZOTRIFLUORIDE is known for its high thermal stability and chemical inertness, making it a valuable building block in the chemical industry. However, it is important to handle this compound with care as it may be harmful if ingested, inhaled, or absorbed through the skin, and it can cause irritation to the eyes and skin.

Upstream product

• 535-52-4 2-fluoro-5-(trifluoromethyl)aniline 
• 454-78-4 3-bromo-4-chlorobenzotrifluoride 
• 32137-19-2 1,2-difluoro-4-(trifluoromethyl)benzene 
• 328-84-7 1,2-dichloro-4-(trifluoromethyl)benzene 

Downstream Products

• 817170-70-0 1-(2-fluoro-4-trifluoromethyl-phenyl)-piperazine 
• 186517-41-9 3-chloro-2-fluoro-6-(trifluoromethyl)benzoic acid 

Relevant articles and documents

Large-scale preparation of aromatic fluorides via electrophilic fluorination with functionalized aryl- or heteroarylmagnesium reagents

Functionalized aryl- or heteroarylmagnesium reagents, prepared from the corresponding bromides or iodides using halogen-magnesium exchange or direct magnesium insertion in the presence of lithium chloride, reacted smoothly with N-fluorobenzenesulfonimide, (PhSO2)2NF, in the mixed solvent (4:1 CH2Cl2-perfluorodecalin) to give the corresponding aromatic fluorides in moderate to good yields. Georg Thieme Verlag Stuttgart · New York.

AROMATIC FLUORINE CHEMISTRY. PART 1. 3,4-DIFLUOROBENZOIC ACID AND DERIVATIVES VIA 3,4-DIFLUOROBENZOTRIFLUORIDE

The preparation of 3,4-difluorobenzotrifluoride from 3,4-dichlorobenzotrifluoride by a KF exchange reaction is described.The conversion of 3,4-difluorobenzotrifluoride to 3,4-difluorobenzoic acid and derivatives is also reported.

THE FLUORINATION OF ORGANIC SUBSTRATES WITH TETRAPHENYLPHOSPHONIUM HYDROGENDIFLUORIDE

Tetraphenylphosphonium hydrogendifluoride acts as a powerful source of F- in various reactions with organic substrates to give fluorine containing products.