32155-34-3Relevant articles and documents
Poly(diphenanthrenequinone-substituted norbornene) for long life and efficient lithium battery cathodes
Kawai, Takuma,Nakao, Satoshi,Nishide, Hiroyuki,Oyaizu, Kenichi
, p. 721 - 727 (2018)
-
Visible Light-Initiated Bioorthogonal Photoclick Cycloaddition
Li, Jinbo,Kong, Hao,Huang, Lei,Zheng, Mengmeng,Yan, Zheng,Zhang, Yan,Cheng, Bo,Qin, Ke
, p. 14542 - 14546 (2018)
Here we report a visible light-triggered, catalyst free bioorthogonal reaction that proceeds via a distinct pathway from reported bioorthogonal reactions. The prototype of this bioorthogonal reaction was the photocycloaddition of 9,10-phenanthrenequinone with electron-rich alkenes to form fluorogenic [4+2] cycloadducts. The bioorthogonal photoclick cycloaddition was readily initiated using a conventional visible light source such as a hand-held LED lamp. The reaction proceeded rapidly under biocompatible conditions, without observable competition from side reactions such as nucleophilic additions by water or common nucleophilic species. The bioorthogonal functionality in this reaction did not cross react with various alkynes and electron-deficient alkenes such as monomethyl fumarate. We demonstrated orthogonal labeling of two proteins using this reaction together with a strain promoting azide-alkyne click reaction or the UV-triggered reaction of tetrazole with monomethyl fumarate. The application of this reaction in the temporal and spatial labeling of live cells was also demonstrated.
COMPOSITIONS AND METHODS OF MAKING EXPANDED HEMATOPOIETIC STEM CELLS USING PTEN INHIBITORS
-
, (2018/12/13)
This invention is directed to, inter alia, compounds, methods, systems, and compositions for the maintenance, enhancement, and expansion of hematopoietic stem cells derived from sources of non-mobilized peripheral blood. Also provided herein are compounds of Formula I which are useful in maintaining, enhancing, and expanding of hematopoietic stem cells.