321863-21-2

Basic information

• Product Name: 1-PALMITOYL-2-OLEOYL-SN-GLYCERO-3-[PHOSPHO-L-SERINE](SODIUM SALT)
• Synonyms: 1-PALMITOYL-2-OLEOYL-SN-GLYCERO-3-[PHOSPHO-L-SERINE](SODIUM SALT);16:0-18:1 PS (SODIUM SALT);(2S,8R,18Z)- 2-Amino-5-hydroxy-10-oxo-8-[[(1-oxohexadecyl)oxy]methyl]-4,6,9-trioxa-5-phosphaheptacos-18-enoic acid 5-oxide monosodium salt;1-Hexadecanoyl-2-(cis-9-octadecenoyl)-sn-glycero-3-phospho-L-serine sodium salt;2-Oleoyl-1-palmitoyl-sn-glycero-3-phospho-L-serine sodium salt;3-sn-Phosphatidyl-L-serine, 2-oleoyl-1-palmi;PS(16：0/18：1(9Z));16:0-18:1 PS (POPS)
• CAS NO: 321863-21-2
• Molecular Formula: C40H75NNaO10P
• Molecular Weight: 783.99
• Mol File: 321863-21-2.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: ?20°C
• CAS DataBase Reference: 1-PALMITOYL-2-OLEOYL-SN-GLYCERO-3-[PHOSPHO-L-SERINE](SODIUM SALT)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PALMITOYL-2-OLEOYL-SN-GLYCERO-3-[PHOSPHO-L-SERINE](SODIUM SALT)(321863-21-2)
• EPA Substance Registry System: 1-PALMITOYL-2-OLEOYL-SN-GLYCERO-3-[PHOSPHO-L-SERINE](SODIUM SALT)(321863-21-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 321863-21-2(Hazardous Substances Data)

Usage

Description

1-PALMITOYL-2-OLEOYL-SN-GLYCERO-3-[PHOSPHO-L-SERINE](SODIUM SALT), also known as Phosphoserine/phosphatidylserine (PS), is an endogenous phospholipid found in all polyanionic macromolecules. It is a reagent that can trigger the release of 5-Aminolevulinic acid (5-ALA) from stealth liposomes and is characterized by its negatively charged membrane lipid.

Uses

Used in Pharmaceutical Applications:
1-PALMITOYL-2-OLEOYL-SN-GLYCERO-3-[PHOSPHO-L-SERINE](SODIUM SALT) is used as a reagent for triggering the release of 5-Aminolevulinic acid (5-ALA) from stealth liposomes. This application is significant in the pharmaceutical industry due to its potential role in drug delivery and targeting specific diseases.
Used in Membrane Biophysics:
In the field of membrane biophysics, 1-PALMITOYL-2-OLEOYL-SN-GLYCERO-3-[PHOSPHO-L-SERINE](SODIUM SALT) is used to form negatively charged lipid bilayers. Molecular dynamics simulations have shown that Na+ ions can penetrate unexpectedly far into the bilayer, well beyond the hydrophilic end groups, providing insights into the behavior of charged lipids in biological membranes.
Used in Liposome Technology:
1-PALMITOYL-2-OLEOYL-SN-GLYCERO-3-[PHOSPHO-L-SERINE](SODIUM SALT) is utilized in the development of liposome technology, particularly in the creation of stealth liposomes. These liposomes have the ability to encapsulate and release various molecules, such as 5-Aminolevulinic acid (5-ALA), making them valuable in drug delivery systems and targeted therapies.
Used in the Study of Polyanionic Macromolecules:
As an endogenous phospholipid found in all polyanionic macromolecules, 1-PALMITOYL-2-OLEOYL-SN-GLYCERO-3-[PHOSPHO-L-SERINE](SODIUM SALT) is used in research to better understand the structure, function, and interactions of these macromolecules in various biological processes and diseases.

Biochem/physiol Actions

Phosphoserine?(PS) can be used as a template for the recognition of cancer antigen 125 (CA 125). It is very essential for healthy nerve cell membranes and myelin. Exogenous PS can be actively absorbed in humans. It has the ability to cross the blood-brain barrier. It plays a key role in the formation of short-term memory, the ability to create new memories, to focus attention, to reason and solve problems and several other cognitive activities. It actively participates in the locomotor functions, like rapid reactions and reflexes.