32188-75-3

Basic information

• Product Name: 5-NITRO-2-PIPERIDINOBENZENECARBONITRILE
• Synonyms: 5-NITRO-2-PIPERIDINOBENZENECARBONITRILE;5-Nitro-2-piperidin-1-ylbenzonitrile;5-nitro-2-(1-piperidinyl)Benzonitrile;5-Nitro-2-(piperidin-1-yl)
• CAS NO: 32188-75-3
• Molecular Formula: C₁₂H₁₃N₃O₂
• Molecular Weight: 231.25052
• Mol File: 32188-75-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 56-59
• Boiling Point: 414.9 °C at 760 mmHg
• Flash Point: 204.7 °C
• Appearance: /
• Density: 1.27 g/cm³
• Vapor Pressure: 4.3E-07mmHg at 25°C
• Refractive Index: 1.602
• Storage Temp.: 2-8°C
• PKA: -0.15±0.40(Predicted)
• CAS DataBase Reference: 5-NITRO-2-PIPERIDINOBENZENECARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-NITRO-2-PIPERIDINOBENZENECARBONITRILE(32188-75-3)
• EPA Substance Registry System: 5-NITRO-2-PIPERIDINOBENZENECARBONITRILE(32188-75-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 32188-75-3(Hazardous Substances Data)

Usage

General Description

5-NITRO-2-PIPERIDINOBENZENECARBONITRILE is a chemical compound with the molecular formula C11H9N3O2. It is a nitro-substituted piperidine derivative that is commonly used as an intermediate in the synthesis of pharmaceuticals and organic compounds. The compound is a white to light yellow crystalline solid with a melting point of approximately 164-166°C. It is soluble in organic solvents such as acetone, dichloromethane, and ethyl acetate, but insoluble in water. 5-NITRO-2-PIPERIDINOBENZENECARBONITRILE is widely used in the pharmaceutical industry for the production of various drugs and medications. Due to its potentially hazardous nature, it should be handled with care and stored in a cool, dry place away from direct sunlight and sources of ignition.

InChI:InChI=1/C12H13N3O2/c13-9-10-8-11(15(16)17)4-5-12(10)14-6-2-1-3-7-14/h4-5,8H,1-3,6-7H2

Upstream product

• 110-89-4 piperidine 
• 17417-09-3 2-fluoro-5-nitrobenzonitrile 
• 16588-02-6 4-chloro-3-cyanonitrobenzene 
• 16588-15-1 2-chloro-5-nitro-benzamide 
• 2516-96-3 2-chloro-5-nitrobenzoic acid 

Downstream Products

• 288249-78-5 ethyl N-(3-cyano-4-piperidinophenyl)-N-[1-(4-fluorophenyl)pyrrol-2-ylcarbonyl]glycine 
• 288250-35-1 1-(4-chlorophenyl)-N-(3-cyano-4-piperidinophenyl)-5-methylpyrazole-4-carboxamide 
• 288249-74-1 N-(3-cyano-4-piperidinophenyl)-1-(4-fluorophenyl)pyrrole-2-carboxamide 
• 288249-80-9 N-[3-cyano-4-piperidinophenyl]-1-(4-fluorophenyl)pyrrole-3-carboxamide 
• 34595-33-0 5-amino-2-(piperidin-1-yl)benzonitrile 
• 50891-30-0 5-Nitro-2-piperidino-benzamid 
• 143675-92-7 (Z)-5-Nitro-2-piperidino-benzamidoxim 

Relevant articles and documents

A class of 4, 5 - disubstituted imidazole derivatives and its preparation and use (by machine translation)

The invention relates to a compound of general formula I indicated by the 4, 5 - disubstituted imidazole compound, or its pharmaceutically acceptable salt, pharmaceutical composition containing the same and its preparation and use, the compounds can be used as a xanthine oxidase (Xanthine oxidase, XO) inhibitor, used for the treatment of uric acid crystallization at the joints to the deposition of Gout and its complications. (by machine translation)

Substituted compounds derived from N-(benzyl)phenylacetamide, preparation and uses

This invention relates to poly-substituted derivatives of the N-(benzyl)phenylacetamide type, pharmaceutical compositions comprising same, therapeutic uses thereof, more particularly in the fields of human and animal health. This invention also relates to a process for the preparation of such derivatives.

AMIDE COMPOUNDS AND MEDICINAL USE THEREOF

The present invention relates to a compound of the formula wherein R1 is substituted aryl, heteroaryl and the like, R2 and R3 are hydrogen, alkyl, halogen, hydroxyl group and the like, Q is N, CH and the like, W is hydrogen, alkyl, hydroxycarbonylalkyl and the like, X is halogen, cyano, nitro, amino and the like, X' is hydrogen, halogen, cyano, nitro, and Y is alkyl, hydroxyl group, alkoxy, mercapto and the like and a salt thereof, and a medicine containing the said compound. The compound of the present invention shows a superior inhibitory effect on activated lymphocytes proliferation and is useful as an agent for the prophylaxis or treatment of various autoimmune diseases.