322407-34-1Relevant articles and documents
Asymmetric amination of meso-epoxide with vegetable powder as a low-toxicity catalyst
Asano, Tatsuhiro,Kurata, Hiroyuki,Takeuchi, Yuki,Tsuzaki, Kazuya,Wada, Koichi
, (2020/08/11)
This paper describes the scope and limitation of substrates subjected to asymmetric amination with epoxides catalyzed by a soluble soybean polysaccharide (Soyafibe S-DN), which we recently discovered from the reaction of 1,2-epoxycyclohexane with cyclopropylamine. Various meso-epoxides reacted with various amines afforded the corresponding products with good enantiomeric selectivity. Since it was found that pectin was found to have a catalytic ability after screening commercially available polysaccharides, we studied 33 different vegetable powders having pectic substances, and we found that many vegetable powders showed catalytic ability. These results should guide in using vegetable components as low-toxic catalysts for the production of pharmaceuticals.
THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF
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Paragraph 0653; 0656; 0657, (2018/04/26)
The invention provides a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein the variables X, Y1-Y5, R1, R2, R3, R4, and Het have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
CYCLOHEXANEDIAMINE COMPOUNDS AND METHODS FOR THEIR PREPARATION
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Paragraph 0106; 0107; 0108; 0109; 0110; 0111, (2014/10/04)
The present invention provides processes for the preparation of cyclohexanediamine compounds of formula Ia and intermediates thereof. The compounds are useful as Syk kinase inhibitors and in various pharmaceutical compositions, and particularly useful for treating conditions mediated at least in part by Syk kinase activity.