322764-97-6

Basic information

• Product Name: isoconazole
• Synonyms: 1H-Imidazole, 1-[(2R)-2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]- (9CI)
• CAS NO: 322764-97-6
• Molecular Formula: C₁₈H₁₄Cl₄N₂O
• Molecular Weight: 416.13
• Mol File: 322764-97-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: isoconazole(CAS DataBase Reference)
• NIST Chemistry Reference: isoconazole(322764-97-6)
• EPA Substance Registry System: isoconazole(322764-97-6)

Safety Data

• Hazardous Substances Data: 322764-97-6(Hazardous Substances Data)

Relevant articles and documents

HPLC method for separating enantiomers of imidazole derivatives - Antifungal compounds

The aim of this study was to test separation possibility of enantiomers of nine active substances belonging to imidazole derivatives: bifonazole, butoconazole, econazole, enilconazole, fenticonazole, isoconazole, miconazole, sertaconazole and tioconazole. The study was performed using HPLC method and the CHIRALCEL OJ column (10 μm; 250 × 4.6 mm), the mobile phase flow rate of 0.8 mL/min and detection at 220 nm. Mobile phases containing hexane and the following modifiers: alcohols (2-propanol, ethanol, methanol) and diethylamine were tested. At first isocratic elution was used but some enantiomers eluted after a long retention time and their peaks were asymmetrical and too wide. Therefore, a gradient elution was developed allowing to obtain satisfactory retention times and other parameters of enentioseparation of the compounds.