32289-58-0 Usage
Description
Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride, commonly known as Polyhexamethylene biguanide hydrochloride (PHMB), is a cationic polymer with broad-spectrum antimicrobial and antifungal properties. It is known for its effectiveness against various types of bacteria, fungi, and other microorganisms. PHMB is a colorless to pale yellow solution and is used in various applications due to its ability to bind and disrupt cytoplasmic membranes of microorganisms.
Uses
Used in Ophthalmology:
Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride is used as a treatment agent for Acanthamoeba keratitis, a rare but serious eye infection. It is also an ingredient in multipurpose contact lens solutions, such as Renu by Bausch & Lomb, to prevent eye infections.
Used in Surface Disinfection:
Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride is used as a surface disinfectant, effective against a wide range of microorganisms, including bacteria and fungi. It is suitable for skin disinfection, although it has a slower effect compared to some other disinfectants.
Used as an Alternative to Benzalkonium Chloride:
In some applications, Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride is used as an alternative to benzalkonium chloride due to its lower foam production under use conditions, making it more suitable for certain environments.
Used in Dermatological Applications:
Polyhexamethylene biguanide (PHMB) is used in dermatological applications under the name polihexanide (INN) and is sold under various brand names such as Lavasept, Serasept, Prontosan, and Omnicide. It is effective against various bacteria, including Pseudomonas aeruginosa, Staphylococcus aureus (including MRSA), Escherichia coli, and fungi like Candida albicans and Aspergillus brasiliensis.
Used in Antimicrobial Applications in Various Industries:
Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride is used as a broad-spectrum antimicrobial polymer in different industries, such as healthcare, agriculture, and water treatment, to control the growth of harmful microorganisms and maintain cleanliness and safety.
Safety
On the 20th of April 2018, the european commission decided to ban preservative uses of PHMB PT9 (Fibre, leather, rubber and polymerised materials preservatives). It’s still allowed for uses as disinfectants PT2 (Disinfectants and algaecides not intended for direct application to humans or animals). Furthermore, PHMB has been declared as a candidate for substitution by the ECHA.
Biological Activity
Polyhexamethylene biguanide (PHMB) is a cationic polymer with antimicrobial and antiviral properties. It has been commonly accepted that the antimicrobial activity is due to the ability of PHMB to perforate the bacterial phospholipid membrane leading ultimately to its death.
Check Digit Verification of cas no
The CAS Registry Mumber 32289-58-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,2,2,8 and 9 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 32289-58:
(7*3)+(6*2)+(5*2)+(4*8)+(3*9)+(2*5)+(1*8)=120
120 % 10 = 0
So 32289-58-0 is a valid CAS Registry Number.
InChI:InChI=1/C18H40N10.ClH/c1-15(19)24-11-7-3-4-9-13-26-17(21)28-18(22)27-14-10-6-5-8-12-25-16(20)23-2;/h3-14H2,1-2H3,(H2,19,24)(H3,20,23,25)(H5,21,22,26,27,28);1H
