323201-04-3Relevant articles and documents
IMPROVED PRODUCTION METHOD FOR ADEFOVIR DIPIVOXIL
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Page/Page column 6, (2011/06/24)
The present invention relates to an improved method of preparing adefovir dipivoxil of Formula 1. The method of the present invention is characterized by using dimethylsulfoxide as a reaction solvent, and comprises a process of preparing adefovir dipivoxil of Formula 1 by allowing adefovir of Formula 2 to react with chloromethylpivalate at a reaction temperature of 30 to 50°C in the presence of dimethylsulfoxide and triethylamine as solvents.