32362-97-3Relevant articles and documents
One-pot synthesis of 2-alkyl cycloketones on bifunctional Pd/ZrO2 catalyst
Xue, Weiyang,Gu, Bin,Wu, Huiling,Liu, Mengyang,He, Songbo,Li, Jingmei,Rong, Xin,Sun, Chenglin
, (2021/03/26)
2-Alkyl cycloketones are essential chemicals and intermediates for synthetic perfumes and pesticides, which are conventionally produced by multistep process including aldol condensation, separation and hydrogenation. In present work, a batch one-pot cascade approach using aldehydes and cycloketones as the raw materials, and a bifunctional Pd/ZrO2 catalyst was developed for the synthesis of 2-alkyl cycloketones, e.g., cyclohexanone and cycloheptanone. Very high aldehydes (except for paraldehyde with large steric hindrance) conversion and high yields for 2-alkyl cycloketones (e.g., 99 % of conversion for n-butanal and 76 wt.% of yield for 2-butyl cyclohexanone) were obtained at mild temperature of 140 °C. After 10 cycles of reuse, Pd/ZrO2 catalyst showed slight deactivation (ca. 5 % conversion and 10 % yield losses), due to the coke on the catalyst. However, the performance of the catalyst was completely recovered after an oxidative regeneration.
Resolution of Racemic ε-Lactones
Fellous, R.,Lizzani-Cuvelier, L.,Loiseau, M. A.,Sassy, E.
, p. 343 - 346 (2007/10/02)
Kinetic resolution of racemic ε-lactones by Pig Liver Esterase give optically active R (+) ε-lactones.When alkyl group is higher than propyl, Horse Liver Esterase leads to the destruction of the opposite enantiomer.Enantiomeric excess is easily evaluated by G.C. on a chiral stationary phase.
Removal of α-Hydroxy Group of Acyloins and Their Derivatives with Vanadium(II)-THF Complex
Inokuchi, Tsutomu,Kawafuchi, Hiroyuki,Torii, Sigeru
, p. 1895 - 1896 (2007/10/02)
α-Hydroxy ketones (acyloins) and their acetate or mesylate derivatives were reduced to the corresponding ketones in good yields by treatment with 2 complex prepared in situ from VCl3(THF)3 and zinc.