32368-82-4

Basic information

• Product Name: α,α-difluoromethyl p-tolyl sulfoxide
• Synonyms: α,α-difluoromethyl p-tolyl sulfoxide
• CAS NO: 32368-82-4
• Molecular Weight: 190.214
• Mol File: 32368-82-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: α,α-difluoromethyl p-tolyl sulfoxide(CAS DataBase Reference)
• NIST Chemistry Reference: α,α-difluoromethyl p-tolyl sulfoxide(32368-82-4)
• EPA Substance Registry System: α,α-difluoromethyl p-tolyl sulfoxide(32368-82-4)

Safety Data

• Hazardous Substances Data: 32368-82-4(Hazardous Substances Data)

Upstream product

• 1246616-18-1 ethyl α,α-difluoro-(p-tolylsulfinyl)acetate 
• 106-45-6 para-thiocresol 
• 333744-42-6 ethyl 2,2-difluoro-2-[(4-methylphenyl)thio]acetate 

Relevant articles and documents

Aryl Fluoroalkyl Sulfoxides: Optical Stability and pKa Measurement

The enantiomeric separation of aryl trifluoromethyl and difluoromethyl sulfoxides was realized via chiral chromatography. The configurational stability of each set of enantiomers was then studied by thermal enantiomerization. The ΔG≠ values obt

Access towards enantiopure α,α-difluoromethyl alcohols by means of sulfoxides as traceless chiral auxiliaries

A new methodology to access enantiopure α,α-difluoromethyl alcohols is hereby being described. The strategy relies on the use of an enantiopure aryl α,α-difluoromethyl sulfoxide employed as chiral and removable auxiliary for the stereoselective difluoromethylation of carbonyl derivatives. The obtained α,α-difluoro-β-hydroxysulfoxides displayed unprecedented diastereomeric ratios.