3238-60-6 Usage
Description
2-Propylpiperidine is an organic compound with the chemical formula C9H19N. It is a colorless liquid that darkens upon exposure to light and air. It has the ability to polymerize and has a boiling point of 166°C (330.8°F) and a melting point of -2°C (28.4°F). 2-Propylpiperidine exhibits alkaline properties with a pKa value of 3.1 and a density of 0.845 at 20°C (68°F). It is slightly soluble in water and chloroform but readily soluble in most organic solvents.
Uses
Used in Pharmaceutical Industry:
2-Propylpiperidine is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a versatile building block for the development of new drugs with potential applications in treating various medical conditions.
Used in Chemical Synthesis:
Due to its reactivity and solubility in organic solvents, 2-Propylpiperidine is used as a reagent in various chemical synthesis processes. It can be employed to produce a range of organic compounds, contributing to the advancement of the chemical industry.
Used in Research and Development:
2-Propylpiperidine serves as a valuable compound for research purposes, particularly in the fields of organic chemistry and medicinal chemistry. It can be used to study the properties and reactions of piperidine derivatives, leading to a better understanding of their potential applications and the development of new compounds with improved properties.
Synthesis Reference(s)
Tetrahedron Letters, 26, p. 4633, 1985 DOI: 10.1016/S0040-4039(00)98771-9
Health Hazard
Coniine is a highly toxic alkaloid. Thetoxic symptoms from ingestion are weakness,drowsiness, nausea, vomiting, muscle contraction, and labored breathing. A high dosecan cause convulsions, cyanosis, asphyxia,and death. Chronic ingestion of coniine produced adverse reproductive effects and spe cific developmental abnormalities in cattles.LD50 value, oral (mice): 100 mg/kg.
Check Digit Verification of cas no
The CAS Registry Mumber 3238-60-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,2,3 and 8 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 3238-60:
(6*3)+(5*2)+(4*3)+(3*8)+(2*6)+(1*0)=76
76 % 10 = 6
So 3238-60-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H17N/c1-2-5-8-6-3-4-7-9-8/h8-9H,2-7H2,1H3
3238-60-6Relevant articles and documents
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Just et al.
, p. 287,289,290 (1976)
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Leete
, p. 3523 (1963)
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A3-coupling reaction as a strategy towards the synthesis of alkaloids
Carmona, Rafaela C.,Wendler, Edison P.,Sakae, George H.,Comassetoa, Jo?o V.,Santos, Alcindo A. Dos
, p. 117 - 123 (2015/02/19)
A number of aldehydes, alkynols and benzylamines were submitted to A3-coupling reaction, under CuCl catalysis, giving strategically functionalized hydroxy-propargylamines. The procedure allows the use of alkyl as well as aryl aldehydes. Representative substrates were converted into five- and six-membered cyclic alkaloids by sequential one-pot N-debenzylation/triple bond reduction promoted by Pd, followed by a Mitsunobu-type cyclization.
Studies on difficult intramolecular hydroaminations in the context of four syntheses of alkaloid natural products
Dion, Isabelle,Vincent-Rocan, Jean-Francois,Zhang, Lei,Cebrowski, Pamela H.,Lebrun, Marie-Eve,Pfeiffer, Jennifer Y.,Bedard, Anne-Catherine,Beauchemin, Andre M.
, p. 12735 - 12749 (2014/01/17)
Examples of intramolecular alkene hydroaminations forming six-membered ring systems are rare, especially for systems in which the double bond is disubstituted. Such cyclizations have important synthetic relevance. Herein we report a systematic study of these cyclizations using recently developed Cope-type hydroamination methodologies. Difficult intramolecular alkene hydroaminations were used as key steps in syntheses of 2-epi-pumiliotoxin C, coniine, N-norreticuline and desbromoarborescidine A. This effort required the development of optimized hydroamination conditions to improve the efficiency of the cyclizations. Collectively, our results show that Cope-type cyclizations can be achieved on a variety of challenging substrates and proceed under similar conditions for both N-H and N-substituted hydroxylamines.
