32435-61-3 Usage
Description
4-Bromo-3-hydroxyquinoline, also known as 4B3HQ, is a quinoline derivative that is a pale yellow solid with a molecular formula of C9H6BrNO and a molecular weight of 216.05 g/mol. It is a versatile chemical compound with potential applications in various fields.
Uses
Used in Pharmaceutical and Agrochemical Industries:
4-Bromo-3-hydroxyquinoline is used as a building block in the synthesis of pharmaceuticals and agrochemicals due to its unique chemical structure and properties.
Used in Cancer Research:
4-Bromo-3-hydroxyquinoline is used as a potential anti-cancer agent, as it has been studied for its ability to target and inhibit the growth of cancer cells.
Used in Inflammation Treatment:
4-Bromo-3-hydroxyquinoline is used as a potential anti-inflammatory agent, as it has been studied for its ability to reduce inflammation and alleviate symptoms associated with inflammatory conditions.
Used in Analytical Chemistry:
4-Bromo-3-hydroxyquinoline is used as a chelating agent for metal ions, making it useful in various analytical techniques and methods.
Used in Corrosion Inhibition:
4-Bromo-3-hydroxyquinoline is used as a corrosion inhibitor, as it can form stable complexes with metal ions and protect materials from corrosion.
Check Digit Verification of cas no
The CAS Registry Mumber 32435-61-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,2,4,3 and 5 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 32435-61:
(7*3)+(6*2)+(5*4)+(4*3)+(3*5)+(2*6)+(1*1)=93
93 % 10 = 3
So 32435-61-3 is a valid CAS Registry Number.
32435-61-3Relevant articles and documents
Design, Synthesis, and Cytotoxic Screening of New Quinoline Derivatives over MCF-7 Breast Cancer Cell Line
Amal, M. Imam,Islam, Zaki
, p. 1099 - 1109 (2020/12/31)
Abstract: VEGFR-2 inhibition represents an attractive strategy for anticancer drug design. A new series of quinoline derivatives were synthesized and structurally confirmed with different spectroscopic techniques. VEGFR-2 inhibition assay showed that 2-(4-bromoquinolin-3-yloxy)-1-(4-chlorophenyl)ethanone (V) demonstrated potent VEGFR-2 inhibitory activities. In addition, the brominated quinoline (V) exhibit antitumor activity over MCF-7 cell line via cell cycle arrest at G1 phase and apoptosis inducing activity as revealed by cell cycle analysis and Annexin V/FITC staining assays. Moreover, brominated quinoline (V) was proved to upregulate expression of proteins that trigger apoptosis such as increased Bax, decreased Bcl-2 as well as increased Bax/Bcl-2 ratio.
