3245-53-2

Basic information

• Product Name: 1-(3-BROMOPROPOXY)-3,5-DIMETHYLBENZENE
• Synonyms: Ether,3-bromopropyl 3,5-xylyl (7CI,8CI); 3-(3,5-Dimethylphenoxy)propyl bromide;3-(3,5-Xylyloxy)propyl bromide; 3-Bromo-1-(3,5-dimethylphenoxy)propane
• CAS NO: 3245-53-2
• Molecular Formula: C₁₁H₁₅BrO
• Molecular Weight: 243.14
• Mol File: 3245-53-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 314°Cat760mmHg
• Flash Point: 123.8°C
• Appearance: /
• Density: 1.265g/cm³
• Vapor Pressure: 0.000881mmHg at 25°C
• Refractive Index: 1.532
• CAS DataBase Reference: 1-(3-BROMOPROPOXY)-3,5-DIMETHYLBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-BROMOPROPOXY)-3,5-DIMETHYLBENZENE(3245-53-2)
• EPA Substance Registry System: 1-(3-BROMOPROPOXY)-3,5-DIMETHYLBENZENE(3245-53-2)

Safety Data

• Hazardous Substances Data: 3245-53-2(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Odor

Strong, sweet

Uses

a. Synthesis of pharmaceuticals
b. Synthesis of pesticides
c. Synthesis of other industrial chemicals
d. Solvent
e. Intermediate in organic synthesis

Hazardous nature

Yes, must be handled with caution

Potential health effects

a. Skin irritation
b. Eye irritation
c. Respiratory system irritation

Safety precautions

Proper safety measures must be taken when working with this compound

InChI:InChI=1/C11H15BrO/c1-9-6-10(2)8-11(7-9)13-5-3-4-12/h6-8H,3-5H2,1-2H3

Upstream product

• 109-64-8 1,3-dibromo-propane 
• 108-68-9 3,5-Dimethylphenol 

Downstream Products

• 108006-26-4 3-(3,5-dimethylphenoxy)propan-1-amine 
• 39938-94-8 5-(3,5-dimethylphenoxy)-2,2-dimethylpentanenitrile 
• 1544740-96-6 3-((4’-((4-cyano-4-methylpentyl)oxy)-2’,6’-dimethyl-[1,1‘-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid 
• 1544740-98-8 ethyl 3-((4’-((4-cyano-4-methylpentyl)oxy)-2’,6’-dimethyl-[1,1’-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate 
• 1544740-97-7 5-(4-bromo-3,5-dimethylphenoxy)-2,2-dimethylpentanenitrile 
• 216968-16-0 3-{3,5-bis-[3-(3,5-dimethyl-phenoxy)-propoxy]-phenoxy}-propan-1-ol 
• 2592-31-6 N-<2-(2-Methoxy-phenoxy)-aethyl>-3-(3,5-dimethyl-phenoxy)-propylamin 

Relevant articles and documents

A light-driven molecular machine based on stiff stilbene

We report a new molecular design for optically triggered nm-scale translation of a submolecular component relative to another. We used a rotaxane-like molecule terminated at one end with stiff stilbene that served both as a chromophore to trigger the tran

Discovery and structure-activity relationship studies of N-substituted indole derivatives as novel Mcl-1 inhibitors

Myeloid cell leukemia-1 (Mcl-1) is an important antiapoptotic protein functioning through protein-protein interactions. We discovered LSL-A6 (2-((2-carbamoyl-1-(3-(4-methoxyphenoxy)propyl)-1H-indol-6-yl)oxy)acetic acid) with a novel N-substituted indole scaffold to interfere Mcl-1 binding as a novel Mcl-1 inhibitor. Molecular modeling indicated that this compound binds with Mcl-1 by interaction with P2 and R263 hot-spots. Structure modification focused on several moieties including indole core, hydrophobic tail and acidic chain were conducted and structure-activity relationship was analyzed. The most potent compound 24d which exhibited Ki value of 110?nM for interfering Mcl-1 binding was obtained after hit-to-lead modification.

ANTIDIABETIC TRICYCLIC COMPOUNDS

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.