3245-55-4Relevant articles and documents
Synthesis and evaluation of anticonvulsant activity of N -(2,5-dimethylphenoxy)-and N-[(2,3,5-trimethylphenoxy)alkyl] aminoalkanols
Waszkielewicz, Anna Maria,Gunia-Krzyzak, Agnieszka,Ceg? A, Marek,Marona, Henryk
, p. 89 - 99 (2015/02/05)
AseriesofnewN-(2,5-dimethylphenoxy)-andN-(2,3,5-trimethylphenoxy)alkylaminoalkanols [I-XVII]wassynthesizedandevaluatedforanticonvulsantactivity.Pharmacologicaltestsincludedmaximal electroshock(MES)andsubcutaneouspentetrazoleseizurethreshold(scMet)assaysaswellasneurotoxicity (TOX)evaluationinmiceafterintraperitoneal(i.p.)administrationand/orinratsafteroral(p.o.)administration. ThemostactivecompoundwasR-2N-[(2,3,5-trimethylphenoxy)ethyl]aminobutan-1-ol,whichexhibited 100%activityinMESatthedoseof30mg/kgbodyweight(mice,i.p.)and75%activityinMESat30mg/kg b.w.(rats,p.o.)withoutneurotoxicityattheactive doses.
Selectivity in alkylation of phenols with 1-bromo-3-chloropropane using phase-transfer catalysis
Reinholz,Becker,Hagenbruch,Schafer,Schmitt
, p. 1069 - 1071 (2007/10/02)
The use of various phase-transfer catalysts in the alkylation of phenol and substituted phenols with 1-bromo-3-chloropropane was investigated. When a quarternary ammonium salt of the general formula R'4N+ X-, where R' = alkyl with a minimum chain length of 4 was used, a mixture of 1-aryloxy-3-chloropropane and 1-aryloxy-3-bromopropane resulted. The effect of counterion, added potassium bromide, and catalysts other than quarternary ammonium salts were assessed for the halopropylation of 2,5-dimethylphenol.