3251-69-2 Usage
Description
4-Imidazoleacetic acid hydrochloride, also known as Imidazole-4-acetic acid monohydrochloride, is a white to light yellow crystalline powder. It is an imidazole derivative with potential applications in various fields due to its unique chemical properties.
Uses
Used in Pharmaceutical Industry:
4-Imidazoleacetic acid hydrochloride is used as a GABAc antagonist for its potential role in the treatment of various neurological disorders. It modulates the GABAc receptors, which are involved in the regulation of neuronal excitability and synaptic transmission.
Used in Nanoparticle Preparation:
4-Imidazoleacetic acid hydrochloride is used as a key component in the preparation of imidazolyl-polyethylenimine modified nanoparticles. These nanoparticles have potential applications in drug delivery and targeted therapy due to their unique properties and ability to encapsulate and release drugs.
Used in Chemical Synthesis:
4-Imidazoleacetic acid hydrochloride is used as a starting material or intermediate in the synthesis of various compounds, such as pyridyl and imidazoyl functionalized carboproteins, potential metal ion chelators, and acyl guanidine inhibitors of beta-secretase. These compounds have potential applications in various industries, including pharmaceuticals, materials science, and environmental management.
Used in Antitubercular Agents:
4-Imidazoleacetic acid hydrochloride acts as an imidazole derivative with potential antituberculous properties. It can be used in the development of new drugs to combat tuberculosis, a global health concern.
Check Digit Verification of cas no
The CAS Registry Mumber 3251-69-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,2,5 and 1 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 3251-69:
(6*3)+(5*2)+(4*5)+(3*1)+(2*6)+(1*9)=72
72 % 10 = 2
So 3251-69-2 is a valid CAS Registry Number.
InChI:InChI=1/C5H6N2O2/c8-5(9)1-4-2-6-3-7-4/h2-3H,1H2,(H,6,7)(H,8,9)/p-1
3251-69-2Relevant articles and documents
Discovery of α-Substituted Imidazole-4-acetic Acid Analogues as a Novel Class of ρ1γ-Aminobutyric Acid Type A Receptor Antagonists with Effect on Retinal Vascular Tone
Krall, Jacob,Brygger, Benjamin M.,Sigureardóttir, Sara B.,Ng, Clarissa K. L.,Bundgaard, Christoffer,Kehler, Jan,Nielsen, Birgitte,Bek, Toke,Jensen, Anders A.,Fr?lund, Bente
, p. 2299 - 2310 (2016/10/25)
The ρ-containing γ-aminobutyric acid type A receptors (GABAARs) play an important role in controlling visual signaling. Therefore, ligands that selectively target these GABAARs are of interest. In this study, we demonstrate that the partial GABAAR agonist imidazole-4-acetic acid (IAA) is able to penetrate the blood–brain barrier in vivo; we prepared a series of α- and N-alkylated, as well as bicyclic analogues of IAA to explore the structure–activity relationship of this scaffold focusing on the acetic acid side chain of IAA. The compounds were prepared via IAA from l-histidine by an efficient minimal-step synthesis, and their pharmacological properties were characterized at native rat GABAARs in a [3H]muscimol binding assay and at recombinant human α1β2γ2Sand ρ1GABAARs using the FLIPR membrane potential assay. The (+)-α-methyl- and α-cyclopropyl-substituted IAA analogues ((+)-6 a and 6 c, respectively) were identified as fairly potent antagonists of the ρ1GABAAR that also displayed significant selectivity for this receptor over the α1β2γ2SGABAAR. Both 6 a and 6 c were shown to inhibit GABA-induced relaxation of retinal arterioles from porcine eyes.
