32511-34-5 Usage
Description
(R)-(+)-Bornylamine is a white crystalline compound that plays a significant role in the field of chemical synthesis and pharmaceutical applications. It is particularly useful in the crystallization-induced chiral inversion of (S)-2-bromo-3-phenylpropanoic acid to its (R)-enantiomer and in the synthesis of trans-bis(R)-(+)-bornylaminopalladium(II) dichloride, a potent antitumor palladium(II) complex.
Uses
Used in Pharmaceutical Industry:
(R)-(+)-Bornylamine is used as a key intermediate in the synthesis of various pharmaceutical compounds, particularly those with antitumor properties. Its ability to induce chiral inversion and its involvement in the synthesis of potent antitumor palladium(II) complexes make it a valuable asset in the development of new cancer treatments.
Used in Chemical Synthesis:
(R)-(+)-Bornylamine serves as an essential building block in the synthesis of complex organic molecules, including those with potential applications in various industries such as pharmaceuticals, agrochemicals, and materials science. Its unique chemical properties and reactivity contribute to the development of novel compounds with diverse applications.
Used in Chiral Inversion:
(R)-(+)-Bornylamine is used as a chiral inducer in the crystallization-induced chiral inversion process, converting (S)-2-bromo-3-phenylpropanoic acid to its (R)-enantiomer. This process is crucial in obtaining specific enantiomers with desired biological activities, which is essential in the development of enantiomerically pure drugs.
Used in Synthesis of Palladium(II) Complexes:
(R)-(+)-Bornylamine is used in the synthesis of trans-bis(R)-(+)-bornylaminopalladium(II) dichloride, a palladium(II) complex with significant antitumor activity. This complex has the potential to be developed into a new class of anticancer drugs, offering alternative treatment options for various types of cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 32511-34-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,2,5,1 and 1 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 32511-34:
(7*3)+(6*2)+(5*5)+(4*1)+(3*1)+(2*3)+(1*4)=75
75 % 10 = 5
So 32511-34-5 is a valid CAS Registry Number.
InChI:InChI=1/C10H19N/c1-9(2)7-4-5-10(9,3)8(11)6-7/h7-8H,4-6,11H2,1-3H3/t7-,8+,10+/m1/s1
32511-34-5Relevant articles and documents
CYANO-PYRIMIDINE INHIBITORS OF EGFR/HER2
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Page/Page column 58-59, (2021/07/17)
Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders associated with EGFR and/or HER2 activity.
New chemical agents based on adamantane-monoterpene conjugates against orthopoxvirus infections
Agafonov, Alexander P.,Bormotov, Nikolay I.,Korchagina, Dina V.,Maksyutov, Rinat A.,Mozhaytsev, Evgenii S.,Salakhutdinov, Nariman F.,Serova, Olga A.,Shishkina, Larisa N.,Suslov, Evgenii V.,Volcho, Konstantin P.,Yarovaya, Olga I.
, p. 1185 - 1195 (2020/11/03)
Currently, the spectrum of agents against orthopoxviruses, in particular smallpox, is very narrow. Despite the fact that smallpox is well controlled, there is, for many reasons, a real threat of epidemics associated with this or a similar virus. In order to search for new low molecular weight orthopoxvirus inhibitors, a series of amides combining adamantane and monoterpene moieties were synthesized using 1- and 2-adamantanecarboxylic acids as well as myrtenic, citronellic and camphorsulfonic acids as acid components. The produced compounds exhibited high activity against the vaccinia virus (an enveloped virus belonging to the poxvirus family), which was combined with low cytotoxicity. Some compounds had a selectivity index higher than that of the reference drug cidofovir; the highest SI = 1123 was exhibited by 1-adamantanecarboxylic acid amide containing the (-)-10-amino-2-pinene moiety. The produced compounds demonstrated inhibitory activity against other orthopoxviruses: cowpox virus (SI = 30-406) and ectromelia virus (mousepox virus, SI = 39-707). This journal is
Diastereoselective desymmetrization of diarylphosphinous acid-borane amides under Birch reduction
Stankevi?, Marek
, p. 6082 - 6102 (2015/06/08)
Treatment of diarylphosphinous acid-borane amides possessing chiral amido functionality with an alkali metal solution in liquid ammonia induced a preferential dearomatization of one aryl substituent at phosphorus leading to the formation of non-equimolar amounts of diastereomers. Diastereoselectivity of dearomatization depends strongly on the structure of a chiral auxiliary.
