32511-35-6Relevant articles and documents
CYANO-PYRIMIDINE INHIBITORS OF EGFR/HER2
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Page/Page column 58-59, (2021/07/17)
Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders associated with EGFR and/or HER2 activity.
New chiral ebselen analogues with antioxidant and cytotoxic potential
Pacu?a, Agata J.,Kaczor, Katarzyna B.,Antosiewicz, J?drzej,D?ugosz, Angelika,Janecka, Anna,Janecki, Tomasz,Wojtczak, Andrzej,?cianowski, Jacek,Santi, Claudio,Bagnoli, Luana,Dembinski, Roman
, (2017/04/03)
New chiral camphane-derived benzisoselenazol-3(2H)-ones and corresponding diselenides have been synthetized using a convenient one-pot procedure. Se-N bond was efficiently converted to an Se-Se bond, which could also be easily re-oxidized to the initial benzisoselenazolone moiety. The antioxidant activity of camphor derivatives was evaluated and compared to the reactivity of a series of N-amino acid benzisoselenazol-3(2H)-ones obtained by a modified procedure involving the improved synthesis and isolation of the diseleno bis(dibenzoic) acid. The most efficient peroxide scavengers, N-bornyl and N-leucine methyl ester benzisoselenazol-3(2H)-ones, were further evaluated as cytotoxic agents on four cancer cell lines (MCF-7, HEP G2, HL 6, and DU 145) and normal cell line PNT1A. The highest antiproliferative potential was evaluated for two compounds bearing a 3-methylbutyl carbon chain, N-leucine methyl ester and N-3-methylbutyl benzisoselenazol-3(2H)-ones.
The effects of added ammonium chloride in the reductive amination of some carbonyl compounds over Ru and Pd catalysts
Ikenaga, Tomoaki,Matsushita, Kumiko,Shinozawa, Junichi,Yada, Satoru,Takagi, Yuzuru
, p. 2105 - 2109 (2007/10/03)
The reductive amination of acetophenone, (+)-camphor, and 5α-cholestan-3-one over Ru and Pd metals as well as their carbon-supported catalysts gave corresponding amines together with alcohols as by-products. However, we found that the corresponding amines are selectively synthesized by the addition of ammonium chloride to the reaction system with depression of the formation of alcohol, as exemplified with acetophenone. Although alcohols are usually not formed over Pd with alicyclic ketones, the alcohols formation was effectively depressed over Ru in the presence of ammonium chloride. The effects of the additive on the stereoselectivity of the formation of amines are also discussed in the cases of (+)-camphor and 5α-cholestan-3-one.