32541-64-3

Basic information

• Product Name: 2,6-dimethoxy-3-nitrobenzoyl chloride
• Synonyms: 2,6-dimethoxy-3-nitrobenzoyl chloride
• CAS NO: 32541-64-3
• Molecular Weight: 245.619
• Mol File: 32541-64-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2,6-dimethoxy-3-nitrobenzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-dimethoxy-3-nitrobenzoyl chloride(32541-64-3)
• EPA Substance Registry System: 2,6-dimethoxy-3-nitrobenzoyl chloride(32541-64-3)

Safety Data

• Hazardous Substances Data: 32541-64-3(Hazardous Substances Data)

Upstream product

• 55776-17-5 2,6-dimethoxy-3-nitrobenzoic acid 

Downstream Products

• 96897-91-5 N-((S)-1-Ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-3-nitro-benzamide 
• 194291-38-8 (3-Amino-2,6-dimethoxy-phenyl)-phenyl-methanone 
• 194291-32-2 (2,6-Dimethoxy-3-nitro-phenyl)-phenyl-methanone 
• 106567-32-2 2,6-Dimethoxy-N,N-dimethyl-3-nitro-benzamide 
• 106567-51-5 2,6-Dimethoxy-N,N-dimethyl-3-nitro-benzamide 
• 106567-20-8 2,6-Dimethoxy-N,N-dimethyl-3-nitro-benzamide 
• 96897-89-1 N-((S)-1-Ethyl-pyrrolidin-2-ylmethyl)-2,6-dimethoxy-3-nitro-benzamide 

Relevant articles and documents

Utility of Complementary Molecular Reactivity and Molecular Recognition (CMR/R) Technology and Polymer-Supported Reagents in the Solution-Phase Synthesis of Heterocyclic Carboxamides

The use of our recently reported chemical library purification strategy in the development of a herbicidal lead, N-(3-benzoylphenyl)-3-(1,1-dimethylethyl)-1-methyl-1H-pyrazole-5-carboxamide (3), is described. The approach applying fundamental properties of complementary molecular reactivity and molecular recognition (CMR/R) as the basis for a general purification strategy was utilized. Polymeric reagents were used in the synthesis to generate reactive species involved in product formation, and complementary molecular reactivity/molecular recognition polymer 8 (CMR/R polymer 8) was used in the solution-phase syntheses of building blocks, primary libraries, and lead refinement libraries. An extension of the CMR/R methodology was applied, utilizing a sequestration enabling reagent (SER), transforming a reactant into an electrophilic species sequestrable by CMR/R polymer 8. This library purification strategy enabled rapid lead generation and lead refinement to afford herbicide 27o. The CMR/R solid-phase purification technique enabled a simple, general, and powerful protocol, eliminating the usual tedious and time-consuming methods required for solution-phase product purification. The result was the synthesis of hundreds of compounds, prepared in a relatively short time, leading to a compound with a 4-fold improvement in herbicidal activity over the initial lead.

Chromatographic Separation of Enantiomers and Barriers to Enantiomerization of Axially Chiral Aromatic Carboxamides

The enantiomers (M) and (P) of a series of similar aromatic carboxamides have been, for the first time, investigated analytically and enriched preparatively by liquid chromatography on triacetylcellulose.Enantiomeric purities (7-99percent), specific rotations, and barriers to rotation about the C(sp2)-C(sp2) bond (87 - 120 kJ/mol, Table 5) were determined.These energies are discussed in terms of the size of ortho substituents and of the buttressing effects by meta substituents.