32545-64-5 Usage
Description
[(Cyclohexylamino)methanediyl]bis(phosphonic acid), also known as Cymevene, is a chemical compound that serves as an antiviral medication. It is specifically used for the treatment of cytomegalovirus retinitis in patients with AIDS. [(cyclohexylamino)methanediyl]bis(phosphonic acid) works by inhibiting the replication of the virus, which in turn slows down the progression of the disease. Cymevene belongs to the class of phosphonic acids, which are recognized for their ability to chelate metal ions. It is particularly effective when administered intravenously for treating cytomegalovirus retinitis.
Uses
Used in Pharmaceutical Industry:
[(Cyclohexylamino)methanediyl]bis(phosphonic acid) is used as an antiviral agent for the treatment of cytomegalovirus retinitis in patients with AIDS. It is effective in inhibiting the replication of the virus, which helps slow down the progression of the disease.
Used in Antiviral Applications:
Cymevene is employed as an antiviral medication, specifically targeting cytomegalovirus retinitis in patients with AIDS. By inhibiting the replication of the virus, it helps to control the disease's progression and provides relief to the patients.
Used in Medical Treatments:
As a part of medical treatments for patients with AIDS, [(cyclohexylamino)methanediyl]bis(phosphonic acid) is used to manage and treat cytomegalovirus retinitis, a potentially severe ocular complication that can lead to vision loss if left untreated.
Check Digit Verification of cas no
The CAS Registry Mumber 32545-64-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,2,5,4 and 5 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 32545-64:
(7*3)+(6*2)+(5*5)+(4*4)+(3*5)+(2*6)+(1*4)=105
105 % 10 = 5
So 32545-64-5 is a valid CAS Registry Number.
32545-64-5Relevant articles and documents
Synthesis and biological evaluation of 1-alkylaminomethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii
Galaka, Tamila,Falcone, Bruno N.,Li, Catherine,Szajnman, Sergio H.,Moreno, Silvia N.J.,Docampo, Roberto,Rodriguez, Juan B.
, p. 3663 - 3673 (2019/07/10)
As an extension of our project aimed at the search for new chemotherapeutic agents against Chagas disease and toxoplasmosis, several 1,1-bisphosphonates were designed, synthesized and biologically evaluated against Trypanosoma cruzi and Toxoplasma gondii,
Convenient synthesis of analogs of aminomethylene gem-diphosphonic acid from amines without catalyst
Wu, Mingshu,Chen, Ruyu,Huang, You
, p. 1393 - 1398 (2007/10/03)
A simple, novel, and convenient synthesis of analogs of aminomethylene gem-diphosphonic acids in one-pot from primary and secondary amines in moderate yields was reported without catalyst.
Studies on novel bone resorption inhibitors. I. Synthesis and pharmacological activities of aminomethylenebisphosphonate derivatives
Takeuchi,Sakamoto,Yoshida,Abe,Isomura
, p. 688 - 693 (2007/10/02)
A series of aminomethylenebisphosphonate derivatives was synthesized and evaluated for their antiresorptive activities using a parathyroid hormone (PTH)-induced hypercalcemia model in rats (PIH model). Among these compounds, (cycloheptylamino)methylenebis(phosphonic acid) (3j) was finally selected for further investigation, proving 10-fold as potent as pamidronate in the PIH model and an immobilization bone atrophy model in rats (DA model). The structure-activity relationships of this series of bisphosphonates are discussed.
