3256-57-3

Basic information

• Product Name: Z-ASN-ONP
• Synonyms: N-ALPHA-CARBOBENZOXY-L-ASPARAGINE P-NITROPHENYL ESTER;N-CBZ-L-ASPARAGINE-P-NITROPHENYL ESTER;Z-L-ASPARAGINE P-NITROPHENYL ESTER;Z-L-ASPARAGINE 4-NITROPHENYL ESTER;Z-ASN-ONP;Z-ASPARAGINE-ONP;4-nitrophenyl N2-[(benzyloxy)carbonyl]-L-asparaginate;NALPHA-Benzyloxycarbonyl-L-asparagine-4-nitrophenyl ester
• CAS NO: 3256-57-3
• Molecular Formula: C₁₈H₁₇N₃O₇
• Molecular Weight: 387.34
• EINECS: 221-853-7
• Mol File: 3256-57-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 688.3 °C at 760 mmHg
• Flash Point: 370.1 °C
• Appearance: /
• Density: 1.387
• Vapor Pressure: 8.47E-19mmHg at 25°C
• Refractive Index: 1.604
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Z-ASN-ONP(CAS DataBase Reference)
• NIST Chemistry Reference: Z-ASN-ONP(3256-57-3)
• EPA Substance Registry System: Z-ASN-ONP(3256-57-3)

Safety Data

• WGK Germany: 3
• F: 8
• Hazardous Substances Data: 3256-57-3(Hazardous Substances Data)

Usage

Description

Z-ASN-ONP, also known as Z-Asn-OH-NH2, is an intermediate compound used in the synthesis of polyamine amide spider toxin NSTX-3. It is a white to off-white powder with unique chemical properties that make it a valuable component in the development of neuroprotective agents.

Uses

Used in Pharmaceutical Industry:
Z-ASN-ONP is used as an intermediate in the synthesis of NSTX-3, a potent glutamate receptor antagonist. This makes it a crucial component in the development of neuroprotective agents, which have potential applications in the treatment of neurological disorders and conditions.
Used in Neuroprotective Agent Synthesis:
Z-ASN-ONP is used as a key intermediate in the synthesis of polyamine amide spider toxin NSTX-3. NSTX-3 has shown potential as a neuroprotective agent, making Z-ASN-ONP an essential component in the development of new treatments for neurological disorders and conditions.

InChI:InChI=1/C18H17N3O7/c19-16(22)10-15(20-18(24)27-11-12-4-2-1-3-5-12)17(23)28-14-8-6-13(7-9-14)21(25)26/h1-9,15H,10-11H2,(H2,19,22)(H,20,24)/t15-/m0/s1

Upstream product

• 100-02-7 4-nitro-phenol 
• 2304-96-3 N-benzyloxycarbonyl-L-asparagine 

Downstream Products

• 20987-51-3 S-benzyl-N-(N²-benzyloxycarbonyl-L-asparaginyl)-L-cysteine methyl ester 
• 74216-21-0 Z-Asn-Ala-OH 
• 210777-24-5 (S)-2-(2-{(R)-5-((S)-2-Benzyloxycarbonylamino-3-carbamoyl-propionylamino)-2-[(S)-2-tert-butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionylamino]-pentanoylamino}-acetylamino)-3-phenyl-propionic acid 
• 210777-28-9 Carbonic acid 4-[(S)-2-((R)-4-((S)-2-benzyloxycarbonylamino-3-carbamoyl-propionylamino)-1-{[((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-methyl]-carbamoyl}-butylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-phenyl ester tert-butyl ester 
• 50903-74-7 carbobenzoxy-L-asparaginylglycine tert-butyl ester 
• 93185-73-0 N-(benzyloxycarbonyl)-L-asparaginamide 
• 4816-93-7 N-(N-Benzyloxycarbonyl-L-asparaginyl)-glycin-(glykolsaeureamid-ester) 
• 14608-82-3 N--L-glutamin-<2,4,6-trimethyl-benzylester> 
• 20898-06-0 Cbz-L-Asn-L-Tyr-OMe 
• 16305-94-5 Z-Asn-Gln-NH-NH-Boc 
• 2596-12-5 N-Benzyloxycarbonyl-L-asparaginyl-O-tert.-butyl-L-threonin-tert.-butylester 
• 4976-86-7 benzyloxycarbonylasparaginyl-phenylalanine methyl ester 
• 75893-42-4 Z-Asn-Thr-OMe 
• 1118119-21-3 N(1)2-(Nα-benzyloxycarbonylasparaginyl)-4,8-di(tert-butoxycarbonyl)-N(1)-[N-(N(4)-tert-butoxycarbonyl-4-aminobutyl)-N-(tert-butoxycarbonyl)glycyl]-4,8-diaza-1,12-dodecanediamine 

Relevant articles and documents

New beta-amino-alpha-hydroxycarboxylic acids and their use

The compounds of the invention are β-amino-α-hydroxycarboxylic acid derivatives having the formula (I): wherein:, R1 represents a group of formula R(Z)xA-, wherein R is hydrogen, or a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl or heterocyclic group or R is a group of formula -NRaRbwherein Raand Rbare hydrogen atoms, alkyl groups, unsubstituted or substituted cycloalkyl, heterocyclic, aralkenyl or aryl groups, Z represents oxygen or sulphur;, A represents a group of formula -CO-, -COCO-, -SO-, -SO2- or -CS-; and, x is the cipher 0 or the integer 1;, R2 represents a hydrogen atom, or a substituted or unsubstituted alkyl group;, R3 is hydrogen, or a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl or heterocyclic group;, R4 is a hydrogen atom, a substituted or unsubstituted alkyl, aryl or heterocyclic group;, and, R5 represents a group of formula -B-(CO)-Y-Rcy, wherein, B represents a heterocyclic group unsubstituted or substituted with at least one alkyl group;, Y represents an oxygen atom, a nitrogen atom or a sulphur atom;, y is the integer 1 when Y represents an oxygen atom or a sulphur atom, and 2 when Y represents a nitrogen atom; and, Rcrepresents, is hydrogen, or a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl or heterocyclic group;, and, where there are two groups or atoms represented by Rc, they are the same or different; and, and pharmaceutically acceptable salts and esters thereof.