3259-15-2

Basic information

• Product Name: 2-(4-fluorophenyl)naphtho[1,2-d][1,3]oxazole
• Synonyms: 2-(4-fluorophenyl)naphtho[1,2-d][1,3]oxazole
• CAS NO: 3259-15-2
• Molecular Weight: 263.271
• Mol File: 3259-15-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(4-fluorophenyl)naphtho[1,2-d][1,3]oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-fluorophenyl)naphtho[1,2-d][1,3]oxazole(3259-15-2)
• EPA Substance Registry System: 2-(4-fluorophenyl)naphtho[1,2-d][1,3]oxazole(3259-15-2)

Safety Data

• Hazardous Substances Data: 3259-15-2(Hazardous Substances Data)

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 2834-92-6 1-amino-2-naphthol 
• 135-19-3 β-naphthol 
• 1765-93-1 4-fluoroboronic acid 
• 233-70-5 naphtho[1,2-d]oxazole 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 131-91-9 1-Nitroso-2-naphthol 
• 459-46-1 4-Fluorobenzyl bromide 
• 459-56-3 4-fluorobenzylic alcohol 
• 403-29-2 2-bromo-4'-fluoroacetophenone 

Relevant articles and documents

Microwave-assisted synthesis of 2-substituted naphtho[1,2-d][1,3]oxazoles by reacting 1-nitroso-2-naphthol with allyl bromides and benzyl bromides using FeCl3 as catalyst

Efficient and improved preparation of 2-substituted[1,2-d][1,3]oxazoles by the reaction of 1-nitroso-2-naphthol and allyl bromides, benzyl bromides under microwave condition utilizing FeCl3 as a catalyst with yield ranging from 32% to 72%. Reaction with bromo acetonitrile yields the corresponding 2-cyanonaphthoxazole with 58% yield.

Facile Protocols towards C2-Arylated Benzoxazoles using Fe(III)-Catalyzed C(sp 2 -H) Functionalization and Metal-Free Domino Approach

Considering their growing attention in the field of medicinal chemistry and drug-discovery research, the facile and convenient approaches towards the preparation of 2-aryl benzoxazole derivatives have been described. The transformation is accomplished by using Fe(III)-catalyzed C-H activation of benzoxazoles with boronic acids to obtain a wide range of C2-arylated benzoxazoles in high yields. The developed method excludes the formation of self-coupling compounds as side products. On the other hand, the synthesis of the products is also achieved via a metal-free domino protocol by the reaction between 1-nitroso-2-naphthol and acetophenones using catalytic amounts of CBr 4 in the presence of Cs 2 CO 3 as base. The devised tandem method avoids the use of pre-activated α-haloketones as substrates. Due to their immense impact in marketed drugs and molecules under clinical trial, the described method can be a powerful tool for their synthesis which restricts the use of precious metals as catalyst.

Reaction of 1-nitroso-2-naphthols with α-functionalized ketones and related compounds: The unexpected formation of decarbonylated 2-substituted naphtho[1,2-d][1,3]oxazoles

Reactions between 1-nitroso-2-naphthols and α-functionalized ketones such as α-bromo-, α-chloro-, α-mesyloxy-, α-tosyloxy-, and α-hydroxy ketones under basic conditions delivered 2-substituted naphtho[1,2-d][1,3]oxazoles in a single synthetic operation. T