32597-30-1

Basic information

• Product Name: 2,2-dimethyl-N-(3-nitrophenyl)propanamide
• Synonyms: 2,2-dimethyl-N-(3-nitrophenyl)propanamide
• CAS NO: 32597-30-1
• Molecular Formula: C₁₁H₁₄N₂O₃
• Molecular Weight: 222.24
• Mol File: 32597-30-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,2-dimethyl-N-(3-nitrophenyl)propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-dimethyl-N-(3-nitrophenyl)propanamide(32597-30-1)
• EPA Substance Registry System: 2,2-dimethyl-N-(3-nitrophenyl)propanamide(32597-30-1)

Safety Data

• Hazardous Substances Data: 32597-30-1(Hazardous Substances Data)

Upstream product

• 3282-30-2 pivaloyl chloride 
• 99-09-2 3-nitro-aniline 

Downstream Products

• 41402-58-8 N-(3-aminophenyl)-1,1-dimethylethylcarboxamide 

Relevant articles and documents

Palladium(II)-Catalyzed Oxidative Homo- and Cross-Coupling of Aryl ortho -sp2 C-H Bonds of Anilides at Room Temperature

The preparation of secondary 2,2'-bisanilides has been successfully achieved through an oxidative coupling of aryl ortho-sp2 C-H bonds of anilides in the presence of catalytic Pd(OAc)2 and K2S2O8 as an oxidant in MsOH/CF3CO2H (TFA) at room temperature (25 °C). The aromatic rings of anilides substituted by various electron-donating or electron-withdrawing groups are tolerant in these coupling reactions.

A unified strategy for silver-, base-, and oxidant-free direct arylation of C-H bonds

Here, we report a dual catalytic approach for room temperature direct arylation of C-H bonds with aryldiazonium salts as a simple aryl group donor, also working as an internal oxidant via C-N2 bond cleavage. This unified strategy has been achieved by the synergistic combination of visible-light metal-free photoredox and palladium catalysis under silver-, base- and/or additive-free conditions. The broad substrate scope, functional group tolerance, excellent regioselectivity and redox-neutral conditions of this process make it attractive for the effective synthesis of a wide range of important N-heterocyclic commodities such as dibenzo[b,d]azepine, carbazole and phenanthridine.

Copper-catalyzed synthesis of benzoxazoles via a regioselective C-H functionalization/C-O bond formation under an air atmosphere

(Chemical Equation Presented) An efficient method for the synthesis of functionalized benzoxazoles is described that involves a copper(II)-catalyzed regioselective C-H functionalization/C-O bond formation protocol. The use of dichlorobenzene as a solvent at 160°C allows the use of air as the terminal oxidant in the catalytic synthesis of benzoxazoles in a process that has high functional group tolerance. The presence of a directing group at the meta position markedly improves the reaction efficacy and a variety of 7-substituted benzoxazoles are selectively produced under mild reaction conditions. The mechanism of the reaction is also discussed in this report.