32619-69-5

Basic information

• Product Name: L-Alanine, N-benzoyl-, ethyl ester
• CAS NO: 32619-69-5
• Molecular Formula: C12H15NO3
• Molecular Weight: 221.256
• Mol File: 32619-69-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: L-Alanine, N-benzoyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Alanine, N-benzoyl-, ethyl ester(32619-69-5)
• EPA Substance Registry System: L-Alanine, N-benzoyl-, ethyl ester(32619-69-5)

Safety Data

• Hazardous Substances Data: 32619-69-5(Hazardous Substances Data)

Upstream product

• 5446-46-8 ethyl 2-(benzoylamino)propanoate 
• 952524-02-6 (S)-1-benzoyl-2-(α-acetoxyethyl)benzimidazole 
• 17344-99-9 AlaOEt 
• 1115-59-9 (S)-alanine ethyl ester hydrochloride 
• 65-85-0 benzoic acid 
• 3082-75-5 L-Alanine ethyl ester 
• 98-88-4 benzoyl chloride 

Downstream Products

• 33985-13-6 (S)-N-(2-hydroxy-1-methylethyl)benzamide 
• 458560-71-9 (S)-3-benzyl-4-methyl-[1,2,3]-oxathiazolidine-2,2-dioxide 
• 1413930-74-1 (S)-ethyl 5-(benzylamino)hex-2-ynoate 
• 54159-18-1 ethyl 2-(benzylamino)propanoate 
• 15366-27-5 Benzoyl-L-alanin-hydrazid 
• 89311-28-4 5(S)-1,4-dihydro-5-methyl-3-phenyl<1,2,4>triazin-6(2H)-one 
• 89311-17-1 N-thiobenzoyl S-alanine ethyl ester 

Relevant articles and documents

Generation of Oxyphosphonium Ions by Photoredox/Cobaloxime Catalysis for Scalable Amide and Peptide Synthesis in Batch and Continuous-Flow

Phosphine-mediated deoxygenative nucleophilic substitutions, such as the Mitsunobu reaction, are of great importance in organic synthesis. However, the conventional protocols require stoichiometric oxidants to trigger the formation of the oxyphosphonium i

Clickable coupling of carboxylic acids and amines at room temperature mediated by SO2F2: A significant breakthrough for the construction of amides and peptide linkages

The construction of amide bonds and peptide linkages is one of the most fundamental transformations in all life processes and organic synthesis. The synthesis of structurally ubiquitous amide motifs is essential in the assembly of numerous important molecules such as peptides, proteins, alkaloids, pharmaceutical agents, polymers, ligands and agrochemicals. A method of SO2F2-mediated direct clickable coupling of carboxylic acids with amines was developed for the synthesis of a broad scope of amides in a simple, mild, highly efficient, robust and practical manner (>110 examples, >90% yields in most cases). The direct click reactions of acids and amines on a gram scale are also demonstrated using an extremely easy work-up and purification process of washing with 1 M aqueous HCl to provide the desired amides in greater than 99% purity and excellent yields.

Processes for forming amide bonds and compositions related thereto

The disclosure relates to methods for producing amide bonds and reagents related thereto. In some embodiments, the disclosure relates to methods of producing an amide comprising mixing an O-silylated thionoester and an amine under conditions such that an amide is formed. In another embodiment, the disclosure relates to mixing a thiolacid, a silylating agent, and an amine under conditions such that an amide is formed.