32666-56-1

Basic information

• Product Name: 1-Naphthalenamine,5,8-dihydro-
• Synonyms: 1-Naphthalenamine,5,8-dihydro-;5,8-Dihydro-1-naphthalenamine;5,8-dihydronaphthalen-1-amine
• CAS NO: 32666-56-1
• Molecular Formula: C₁₀H₁₁N
• Molecular Weight: 145.2
• Mol File: 32666-56-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 37.5°C
• Boiling Point: 254.33°C (rough estimate)
• Flash Point: 135.2 °C
• Appearance: /
• Density: 1.0353 (rough estimate)
• Refractive Index: 1.5000 (estimate)
• CAS DataBase Reference: 1-Naphthalenamine,5,8-dihydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Naphthalenamine,5,8-dihydro-(32666-56-1)
• EPA Substance Registry System: 1-Naphthalenamine,5,8-dihydro-(32666-56-1)

Safety Data

• Hazardous Substances Data: 32666-56-1(Hazardous Substances Data)

Usage

General Description

1-Naphthalenamine,5,8-dihydro- is a chemical compound that belongs to the organic class of compounds known as naphthalenamines. This class of compounds is characterized by the presence of a naphthalene moiety to which an amine group is substituted. The molecular structure of 1-Naphthalenamine,5,8-dihydro- consists of a naphthalene backbone with two added hydrogen atoms and one amine functionality. It is relatively less common and used in certain specialized chemical applications. Its properties - reactivity, stability, toxicity have been studied to limited extent due to its uncommon nature and specific use.

Upstream product

• 7732-18-5 water 
• 134-32-7 1-amino-naphthalene 
• 64-17-5 ethanol 
• 108-88-3 toluene 
• 67-56-1 methanol 
• 7664-41-7 ammonia 

Downstream Products

• 529-35-1 5,6,7,8-Tetrahydronaphthalen-1-ol 
• 91374-21-9 Ropinirole 
• 76149-15-0 4-<2-(N,N-di-n-propylamino)ethyl>indole 
• 7499-73-2 N-(4-bromo-2-nitronaphthalen-1-yl)acetamide 
• 120447-37-2 (+/-)-trans-5-acetamido-2-hydroxy-3-(4-phenylpiperidino)tetralin 
• 112628-52-1 (±)-5-amino-3-(4-phenylpiperidin-1-yl)-1,2,3,4-tetrahydronaphthalen-2-ol 

Relevant articles and documents

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Suitable for vesicle acetylecholine translocator detection compound (by machine translation)

The present invention provides a compound represented by formula (I), wherein in formula (I), R 1 represents CH 3 , F, (CH 2 ) n -F, NH-(CH 2 ) n -F, O-(CH 2 ) n -F or S-(CH 2 ) n -F, and n represents an integer of 1 to 3.

New systematically modified vesamicol analogs and their affinity and selectivity for the vesicular acetylcholine transporter - A critical examination of the lead structure

To verify vesamicol as lead structure in the development of radioligands for imaging of VAChT in the brain by PET, we systematically modified this molecule and investigated four different groups of derivatives. Structural changes were conducted in all three ring systems A, B, and C resulting in a library of different vesamicol analogs. Based on their in vitro binding affinity toward VAChT as well as σ1 and σ2 receptors, we performed a structure-affinity relationship (SAR) study regarding both affinity and selectivity. The compounds possessed VAChT affinities in the range of 1.32 nM (benzovesamicol) to >10 mM and selectivity factors from 0.1 to 73 regarding σ1 and σ2 receptors, respectively. We could confirm the exceptional position of benzovesamicols as most affine VAChT ligands. However, we also observed that most of the compounds with high VAChT affinity demonstrated considerable affinity in particular to the σ1 receptor. Finally, none of the various vesamicol analogs in all four groups showed an in vitro binding profile suitable for specific VAChT imaging in the brain.