32685-24-8

Basic information

• Product Name: N-[4-(methylphenyl)sulfonyl]-5-nitro-1H-indole
• Synonyms: N-[4-(methylphenyl)sulfonyl]-5-nitro-1H-indole
• CAS NO: 32685-24-8
• Molecular Weight: 316.337
• Mol File: 32685-24-8.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: N-[4-(methylphenyl)sulfonyl]-5-nitro-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-(methylphenyl)sulfonyl]-5-nitro-1H-indole(32685-24-8)
• EPA Substance Registry System: N-[4-(methylphenyl)sulfonyl]-5-nitro-1H-indole(32685-24-8)

Safety Data

• Hazardous Substances Data: 32685-24-8(Hazardous Substances Data)

Upstream product

• 6146-52-7 5-nitroindole 
• 104-15-4 toluene-4-sulfonic acid 
• 98-59-9 p-toluenesulfonyl chloride 
• 143261-98-7 2-(1-isopropylthio-2-methoxyethyl)-4-nitroaniline 
• 100-01-6 4-nitro-aniline 
• 143262-02-6 N-tosyl-2-(1-isopropylthio-2-methoxyethyl)-4-nitroanilide 

Downstream Products

• 1045601-61-3 N-(2-nitrobenzene)-5-nitroindole 
• 299914-35-5 5-nitro-1-(4-nitrophenyl)-1H-indole 
• 1356564-19-6 C₁₅H₁₃BN₂O₆S 
• 1356564-20-9 C₂₅H₁₉N₇O₄S 
• 639008-13-2 N-benzyl-2-(1H-indole-5-yl)-N-methylethane-1-sulfonamide 
• 495-48-7 azoxybenzene 
• 1235976-59-6 1-(5-nitro-1-p-toluenesulfonyl-1Η-indol-3-yl)ethanone 
• 1349111-31-4 C₂₁H₂₂N₂O₅S 
• 6146-52-7 5-nitroindole 

Relevant articles and documents

Calculated oxidation potentials predict reactivity in Baeyer-Mills reactions

Azobenzenes are widely used as dyes and photochromic compounds, with the Baeyer-Mills reaction serving as the most common method for their preparation. This transformation is often plagued by low yields due to the formation of undesired azoxybenzene. Here, we explore electronic effects dictating the formation of the azoxybenzene side-product. Using calculated oxidation potentials, we were able to predict reaction outcomes and improve reaction efficiency simply by modulating the oxidation potential of the arylamine component.

Imino thiadiazine dioxide derivative, and applications thereof

The invention discloses an imino thiadiazine dioxide derivative, and applications thereof, and more specifically relates to a novel imino thiadiazine dioxide derivative, and a pharmaceutical composition containing the imino thiadiazine dioxide derivative.

Design, synthesis, and biological evaluation of hydantoin bridged analogues of combretastatin A-4 as potential anticancer agents

A series of novel hydantoin-bridged analogues of combretastatin A-4 (CA-4) were designed, synthesized and evaluated for antiproliferative activities in vitro and in vivo. The most potent compound 8d, showed potent cytotoxicity against four human cancer cell lines with IC50 values of 0.186–0.279 μM, and possessed the efficacy of inhibiting tubulin polymerization, disrupting in vitro vascularization, blocking cell cycle in G2/M phase and inducing cell apoptosis. In the nude mice xenograft model, 8d significantly inhibited the tumor growth and showed low toxicity. Further chiral separation proved (R)-(?)-8d to be the preferential enantiomer with IC50 values of 0.081–0.157 M. These results indicated that the hydantoin derivatives merit further investigation as potential anticancer agents that inhibit tubulin polymerization.