326860-05-3 Usage
Description
1-(2-methylphenyl)-1,4-diazepane, also known as 2-Me-DZ or 1-(o-tolyl)-1,4-diazepane, is a chemical compound belonging to the diazepane class. It is a seven-membered heterocyclic compound containing one nitrogen and six carbon atoms. 1-(2-methylphenyl)-1,4-diazepane has been studied for its potential pharmacological properties, including its use as a central nervous system depressant and anxiolytic agent. Its chemical structure and properties make it a potential candidate for therapeutic applications in the treatment of anxiety disorders and other related conditions. Further research is needed to fully understand and harness the potential benefits of 1-(2-methylphenyl)-1,4-diazepane in the medical field.
Uses
Used in Pharmaceutical Industry:
1-(2-methylphenyl)-1,4-diazepane is used as a central nervous system depressant for its potential anxiolytic effects, aiming to alleviate anxiety disorders and related conditions.
Used in Research and Development:
1-(2-methylphenyl)-1,4-diazepane serves as a compound for further research and development in the medical field, particularly in exploring its pharmacological properties and potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 326860-05-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,2,6,8,6 and 0 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 326860-05:
(8*3)+(7*2)+(6*6)+(5*8)+(4*6)+(3*0)+(2*0)+(1*5)=143
143 % 10 = 3
So 326860-05-3 is a valid CAS Registry Number.
326860-05-3Relevant articles and documents
Discovery and structure-activity relationship of thienopyridine derivatives as bone anabolic agents
Saito, Keiji,Nakao, Akira,Shinozuka, Tsuyoshi,Shimada, Kousei,Matsui, Satoshi,Oizumi, Kiyoshi,Yano, Kazuki,Ohata, Keiko,Nakai, Daisuke,Nagai, Yoko,Naito, Satoru
, p. 1628 - 1642 (2013/04/24)
A cell-based assay was performed for the discovery of novel bone anabolic agents. Alkaline phosphatase (ALPase) activity of ST2 cells was utilized as an indicator of osteoblastic differentiation, and thienopyridine derivative 1 was identified as a hit compound. 3-Aminothieno[2,3-b]pyridine-2-carboxamide was confirmed to be a necessary core structure for the enhancement of ALPase activity, and then optimization of the C4-substituent on the thienopyridine ring was carried out. Introduction of cyclic amino groups to the C4-position of the thienopyridine ring improved the activity. Especially, N-phenyl-homopiperazine derivatives were found to be strong enhancers of ALPase among this new series. Furthermore, 3-amino-4-(4-phenyl-1,4-diazepan-1-yl)thieno[2,3-b]pyridine-2- carboxamide (15k) was orally administered to ovariectomized (OVX) rats over 6 weeks for evaluating the effects on areal bone mineral density (aBMD), and statistically significant improvements in aBMD were observed from the dosage of 10 mg/kg/day.
