32730-03-3Relevant articles and documents
Rapid and Selective Detection of Cyanide Anion by Enhanced Fluorescent Emission and Colorimetric Color Changes at Micromole Levels in Aqueous Medium
Qu, Wen-Juan,Li, Wen-Ting,Zhang, Hai-Li,Wei, Tai-Bao,Lin, Qi,Yao, Hong,Zhang, You-Ming
, p. 879 - 887 (2018)
One main source of cyanide (CN?) exposure for mammals is through the plant consumption; thus, the sensitive and selective cyanide detection in plant tissue is a significant and urgent work. Here, a simple sensor N′-(2,4-dihydroxybenzylidene)naphtha[2,1-b]furan-2-carbohydrazide (Q1-3) was designed and synthesized for selective and sensitive dual-channel detection of cyanide in aqueous medium (DMSO/H2O, 1:9, v/v). Acylhydrazone and phenolic hydroxyl groups on Q1-3 are the recognition sites, and naphthofuran group is the signal report group. The intramolecular charge transfer between the benzene group and naphthofuran group was impeded because of the electron-withdrawing groups (hydroxyl) on sensor Q1-3. Interestingly, the sensor Q1-3 exhibited an intramolecular charge transfer absorption band at 400?nm and emission band at 500?nm, respectively, directly realizing an “OFF–ON” response after the deprotonation process induced by cyanide anions in aqueous medium (DMSO/H2O, 1:9, v/v). Notably, this sensor was successfully applied to detect cyanide anions in food samples, which proves a very simple and selective platform for on-site monitoring of cyanide in agriculture samples. In addition, the test strips and silica gel plates based on Q1-3 were also fabricated, which could act as test kits and silica gel plates for convenient and efficient detection of cyanide anions.
Tandem Synthesis of 2-Carboxybenzofurans via Sequential Cu-Catalyzed C-O Coupling and Mo(CO)6-Mediated Carbonylation Reactions
Mo, Qinliang,Sun, Nan,Jin, Liqun,Hu, Baoxiang,Shen, Zhenlu,Hu, Xinquan
, p. 11490 - 11500 (2020/10/12)
A modular tandem synthesis of 2-carboxybenzofurans from 2-gem-dibromovinylphenols has been established based on a sequence of Cu-catalyzed intramolecular C-O coupling and Mo(CO)6-mediated intermolecular carbonylation reactions. This protocol allowed one-step access to a broad variety of functionalized benzofuran-2-carboxylic acids, esters, and amides in good to excellent yields under Pd- and CO gas-free conditions.
Synthesis of oxadiazoles encompassing naphtho [2,1-b] thiophene as novel antimicrobial agents
Kusuma,Vaidya,Nagashree,Mahadevan
, p. 309 - 314 (2013/09/24)
The required starting material ethyl naphtho [2,1-b] furan-2-carboxylate 2 has been synthesized by the reaction between ethyl chloroacetate and 2-hydroxy-1-naphthaldehyde 1, which in turn was obtained by employing Reimer-Tiemann reaction using 2-naphthol. The ester 2 on thionation with phosphorus pentasulphide produced two compounds viz., ethyl naphtho [2,1-b] thiophene-2-carboxylate 3 and ethyl naphtho [2,1-6] furan-2-carbothioate 4. The compounds 3 and 4 were separated by column chromatography and the compound 3 was converted into naphtho [2,1-b] thiophene-2-carbohydrazide 5 by reacting with hydrazine hydrate. The reaction of carbohydrazide 5 with various aromatic aldehydes resulted in the formation of corresponding Schiff bases 6a-e. The synthesis of 5-(naphtho [2,1-b] thiophen-2-yl)-3-(prop-1-en-2-yl)-2,3-dihydro-1, 3,4-oxadiazoles 7a-e was achieved by adopting a simple one pot procedure which involved reaction of Schiff bases 6a-e with acetic anhydride. All the synthesized compounds have been characterized by IR, 1H NMR spectroscopy and mass spectrometry. All the newly synthesized compounds showed moderate to mild antimicrobial activity when evaluated by cup-plate method. These findings indicated that the title compounds have the property to kill the microbes to some extent when compared with standard drug.
