3277-80-3

Basic information

• Product Name: 4-CHLOROPHENYL CYCLOHEXYL KETONE
• Synonyms: 4-CHLOROPHENYL CYCLOHEXYL KETONE;Cyclohexyl(4-chlorophenyl)methanone;OTAVA-BB 1044135;UKRORGSYN-BB BBV-5118695;(4-chlorophenyl)(cyclohexyl)Methanone
• CAS NO: 3277-80-3
• Molecular Formula: C₁₃H₁₅ClO
• Molecular Weight: 222.71
• Mol File: 3277-80-3.mol
• Article Data: 23

Chemical Properties

• Melting Point: 61.5-62.5 °C
• Boiling Point: 337.38°C at 760 mmHg
• Flash Point: 186.552°C
• Appearance: /
• Density: 1.14g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.55
• CAS DataBase Reference: 4-CHLOROPHENYL CYCLOHEXYL KETONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLOROPHENYL CYCLOHEXYL KETONE(3277-80-3)
• EPA Substance Registry System: 4-CHLOROPHENYL CYCLOHEXYL KETONE(3277-80-3)

Safety Data

• Hazardous Substances Data: 3277-80-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H15ClO/c14-12-8-6-11(7-9-12)13(15)10-4-2-1-3-5-10/h6-10H,1-5H2

Upstream product

• 108-90-7 chlorobenzene 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 100-52-7 benzaldehyde 
• 110-83-8 cyclohexene 
• 122-01-0 4-chloro-benzoyl chloride 
• 74-11-3 para-chlorobenzoic acid 
• 52707-91-2 N-(4-chlorobenzoyl) saccharin 
• 126812-30-4 1,3-dioxoisoindolin-2-yl cyclohexanecarboxylate 
• 98-89-5 Cyclohexanecarboxylic acid 
• 108483-22-3 (4-Chloro-phenyl)-(5,5-dimethyl-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-methanol 
• 2043-61-0 cyclohexanecarbaldehyde 
• 6343-28-8 1-(4-chlorobenzoyl)pyrrolidine-2,5-dione 
• 110-82-7 cyclohexane 
• 98446-77-6 1-chloro-4-(cyclohexylmethyl)benzene 

Downstream Products

• 868396-33-2 3-(4-chloro-phenyl)-3-cyclohexyl-3-hydroxy-1-piperidin-1-yl-propan-1-one 
• 1233012-05-9 (Pd(C₆H₃ClCO(cyclo-C₆H₁₁)))2(trifluoroacetate)2 
• 128352-44-3 2-[(Z)-1-Carboxy-2-(4-chloro-phenyl)-2-cyclohexyl-vinyl]-benzoic acid 
• 128352-38-5 2-[(E)-1-Carboxy-2-(4-chloro-phenyl)-2-cyclohexyl-vinyl]-benzoic acid 
• 128352-54-5 6-chloro-2-(o-carboxyphenyl)-3-cyclohexylind-2-enone lactone 
• 128352-47-6 4-[1-(4-Chloro-phenyl)-1-cyclohexyl-meth-(Z)-ylidene]-isochroman-1,3-dione 
• 1029548-00-2 4-chloromethyl-2-(4-chloro-phenyl)-2-cyclohexyl-[1,3]dioxolane 
• 128352-35-2 methyl E-2-(o-carboxyphenyl)-3-cyclohexyl-p-chlorocinnamate 
• 128352-41-0 methyl Z-2-(o-carboxyphenyl)-3-cyclohexyl-p-chlorocinnamate 
• 93765-49-2 (4-Chloro-phenyl)-cyclohexyl-pyrimidin-5-yl-methanol 

Relevant articles and documents

Nickel-Mediated Photoreductive Cross Coupling of Carboxylic Acid Derivatives for Ketone Synthesis**

A simple visible light photochemical, nickel-catalyzed synthesis of ketones from carboxylic acid-derived precursors is presented. Hantzsch ester (HE) functions as a cheap, green and strong photoreductant to facilitate radical generation and also engages in the Ni-catalytic cycle to restore the reactive species. With this dual role, HE allows for the coupling of a large variety of radicals (1°,2°, benzylic, α-oxy & α-amino) with aroyl and alkanoyl moieties, a new feature in reactions of this type. With both precursors deriving from abundant carboxylic acids, this protocol is a welcome addition to the organic chemistry toolbox. The reaction proceeds under mild conditions without the need for toxic metal reagents or bases and shows a wide scope, including pharmaceuticals and complex molecular architectures.

Method for synthesizing aryl ketone compound by taking AQ as photocatalyst

The invention provides a method for synthesizing an aryl ketone compound by taking AQ as a photocatalyst. The method comprises the following steps that AQ serves as a photocatalyst; under the conditions of a palladium catalyst, a phosphine ligand, weak base and an organic solvent, a 390-to-430-nm photocatalysis lamp is used for irradiation at room temperature in an inert protective atmosphere, soan aldehyde group-containing compound reacts with Ar-X, wherein Ar-X is aryl halide or aryl trifluoromethanesulfonic acid, the aryl halide is aryl bromide or aryl iodide, and the aldehyde group-containing compound is one selected from aryl aldehyde, alkyl aldehyde, linear primary aldehyde and acyclic secondary aldehyde. According to the invention, the anthraquinone (AQ) HAT photocatalyst and palladium catalyst are combined for use, C-H arylation and alkenylation reactions of aldehyde can be directly carried out to synthesize ketone, and reaction efficiency is high. The method has the advantages of mild reaction conditions, high yield and a wide substrate application range, and can be used for synthesizing natural products in medicinal plants.

Direct C-H Arylation of Aldehydes by Merging Photocatalyzed Hydrogen Atom Transfer with Palladium Catalysis

Herein, we report that merging palladium catalysis with hydrogen atom transfer (HAT) photocatalysis enabled direct arylations and alkenylations of aldehyde C-H bonds, facilitating visible light-catalyzed construction of a variety of ketones. Tetrabutylammonium decatungstate and anthraquinone were found to act as synergistic HAT photocatalysts. Density functional theory calculations suggested a Pd0-PdII-PdIII-PdI-Pd0 pathway and revealed that regeneration of the Pd0 catalyst and the photocatalyst occurs simultaneously in the presence of KHCO3. This regeneration features a low energy barrier, promoting efficient coupling of the palladium catalytic cycle with the photocatalytic cycle. The work reported herein suggests great promise for further applications of HAT photocatalysis in palladium-catalyzed cross-coupling and C-H functionalization reactions to be successful.