32785-03-8Relevant articles and documents
Chemoenzymatic synthesis of enantiopure hydroxy sulfoxides derived from substituted arenes
Boyd, Derek R.,Sharma, Narain D.,Malone, John F.,Ljubez, Vera,Murphy, Deirdre,Shepherd, Steven D.,Allen, Christopher C. R.
, p. 2651 - 2664 (2016/03/05)
Enantiopure β-hydroxy sulfoxides and catechol sulfoxides were obtained, by chemoenzymatic synthesis, involving dioxygenase-catalysed benzylic hydroxylation or arene cis-dihydroxylation and cis-diol dehydrogenase-catalysed dehydrogenation. Absolute configurations of chiral hydroxy sulfoxides were determined by X-ray crystallography, ECD spectroscopy and stereochemical correlation. The application of a new range of β-hydroxy sulfoxides as chiral ligands was examined.