328081-58-9

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 2-(3,5-difluorophenoxy)-
• CAS NO: 328081-58-9
• Molecular Formula: C14H7F2NO3
• Molecular Weight: 275.211
• Mol File: 328081-58-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 2-(3,5-difluorophenoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 2-(3,5-difluorophenoxy)-(328081-58-9)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 2-(3,5-difluorophenoxy)-(328081-58-9)

Safety Data

• Hazardous Substances Data: 328081-58-9(Hazardous Substances Data)

Upstream product

• 524-38-9 N-hydroxyphthalimide 
• 156545-07-2 3,5-difluorophenylboronic acid 

Downstream Products

• 1443440-60-5 N-(3,5-difluorophenoxy)acetamide 

Relevant articles and documents

The copper-mediated cross-coupling of phenylboronic acids and N-hydroxyphthalimide at room temperature: synthesis of aryloxyamines.

[figure: see text] A novel route to aryloxyamines via the copper-mediated cross-coupling of N-hydroxyphthalimide and phenylboronic acids is reported. The reaction is mediated by selected copper(I) and (II) salts in the presence of pyridine and is tolerant of several functional groups on the phenylboronic acid. The phthallmide group is removed using hydrazine to afford the corresponding aryloxyamine.

Inhibitors of transthyretin amyloid fibril formation

Bisaryloxime ethers and bisarylhydroazones are shown to be effective for inhibiting formation of amyloid fibrils of transthyretin.