32812-52-5

Basic information

• Product Name: (2-bromo-1-phenyl-cyclopropyl)benzene
• CAS NO: 32812-52-5
• Molecular Formula: C₁₅H₁₃Br
• Molecular Weight: 273.172
• Mol File: 32812-52-5.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 343.7°Cat760mmHg
• Flash Point: 146°C
• Density: 1.405g/cm³
• CAS DataBase Reference: (2-bromo-1-phenyl-cyclopropyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: (2-bromo-1-phenyl-cyclopropyl)benzene(32812-52-5)
• EPA Substance Registry System: (2-bromo-1-phenyl-cyclopropyl)benzene(32812-52-5)

Safety Data

• Hazardous Substances Data: 32812-52-5(Hazardous Substances Data)

Usage

Description

(2-bromo-1-phenyl-cyclopropyl)benzene is a chemical compound with the molecular formula C15H13Br. It is a colorless liquid that contains a cyclopropyl ring, a benzene ring, and a bromine atom attached to the cyclopropyl ring. This versatile chemical compound is used in organic synthesis and pharmaceutical research, and serves as a valuable building block for the synthesis of various biologically active compounds and pharmaceutical intermediates.

Uses

Used in Organic Synthesis:
(2-bromo-1-phenyl-cyclopropyl)benzene is used as a building block for the synthesis of various biologically active compounds and pharmaceutical intermediates. Its unique structure and the presence of the bromine atom make it a useful substrate for further chemical reactions.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (2-bromo-1-phenyl-cyclopropyl)benzene is used as a starting material for the development of new drugs and materials. Its potential applications in drug discovery and the synthesis of novel therapeutic agents make it a valuable compound for researchers in this field.
Overall, (2-bromo-1-phenyl-cyclopropyl)benzene is a versatile chemical compound with potential uses in research and industry, particularly in the fields of organic synthesis and pharmaceutical research.

Upstream product

• 98-86-2 acetophenone 
• 108-86-1 bromobenzene 
• 119-61-9 benzophenone 
• 530-48-3 1,1-Diphenylethylene 
• 17343-74-7 1,1-dibromo-2,2-diphenylcyclopropane 

Downstream Products

• 3282-18-6 1,1-diphenylcyclopropane 
• 7150-12-1 2,2-diphenyl-cyclopropanecarboxylic acid 

Relevant articles and documents

Synthesis of Quinolines via the Metal-free Visible-Light-Mediated Radical Azidation of Cyclopropenes

We report the synthesis of quinolines using cyclopropenes and an azidobenziodazolone (ABZ) hypervalent iodine reagent as an azide radical source under visible-light irradiation. Multisubstituted quinoline products were obtained in 34-81% yield. The reaction was most efficient for 3-trifluoromethylcyclopropenes, affording valuable 4-trifluoromethylquinolines. The transformation probably proceeds through the cyclization of an iminyl radical formed by the addition of the azide radical on the cyclopropene double bond, followed by ring-opening and fragmentation.

Stereoselective Synthesis of Vinylcyclopropa[ b]indolines via a Rh-Migration Strategy

A mild rhodium catalytic system has been developed to synthesize vinylcyclopropa[b]indolines through cyclopropanation of indoles with vinyl carbenoids generated from ring opening of cyclopropenes in situ. By employing a Rh-migration strategy, the products can be obtained with good to excellent E:Z ratios (≤99:1) and complete diastereoselectivity (≤99:1). This method is easy, has a low catalyst loading, and works for a broad range of functionalities.

Rhodium-Catalyzed Intermolecular Cyclopropanation of Benzofurans, Indoles, and Alkenes via Cyclopropene Ring Opening

The generation of metal carbenoids via ring opening of cyclopropenes by transition metals offers a simple entry into highly reactive intermediates. Herein, we describe a diastereoselective intermolecular rhodium-catalyzed cyclopropanation of heterocycles and alkenes using cyclopropenes as carbene precursors with a low loading of a commercially available rhodium catalyst. The reported method is scalable and could be performed with catalyst loadings as low as 0.2 mol %, with no impact to the reaction yield or selectivity.