3282-11-9Relevant articles and documents
Single and double Suzuki-Miyaura couplings with symmetric dihalobenzenes
Sinclair, David J.,Sherburn, Michael S.
, p. 3730 - 3733 (2007/10/03)
(Chemical Equation Presented) m- or p-diiodobenzene undergoes selective double coupling reactions with arylboronic acids and esters. Selectivity for double coupling over single coupling is remarkably strong: even with a diiodobenzene:monoboronic acid ratio of 10:1, the products of double coupling are formed in good yields. Steric hindrance and electronic influences of the boronic acid or ester, and reaction conditions do not appear to impact significantly upon the outcome of the reaction. In contrast, m- and p-dibromobenzenes undergo single couplings with aryl boronic acids with high selectivity.
Nondepolarizing muscle relaxant
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, (2008/06/13)
A nondepolarizing muscle relaxant containing, as active principle ingredient, p,p"-bis-triethylammonio-n-terphenyl dibenzenesulphonate in a pharmaceutical carrier is described. The proposed preparation is used as a 0.5 per cent aqueous solution. Said muscle relaxant possesses high potency and selectivity. When given in a myoparalytic dose, it does not affect the arterial pressure. The preparation is nontoxic, its effect is quickly and fully removed by cholinesterase inhibitors, which ensures higher safety and better control of muscle relaxation compared with the action of the known muscle relaxants α-tubocurarin and pancuronium.