328378-31-0

Basic information

• Product Name: 6-(4-methoxyphenyl)-9H-purine
• Synonyms: 6-(4-methoxyphenyl)-9H-purine
• CAS NO: 328378-31-0
• Molecular Weight: 226.238
• Mol File: 328378-31-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 6-(4-methoxyphenyl)-9H-purine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4-methoxyphenyl)-9H-purine(328378-31-0)
• EPA Substance Registry System: 6-(4-methoxyphenyl)-9H-purine(328378-31-0)

Safety Data

• Hazardous Substances Data: 328378-31-0(Hazardous Substances Data)

Upstream product

• 87-42-3 6-chloropurine 
• 7306-68-5 6-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine 
• 5720-07-0 4-methoxyphenylboronic acid 
• 328378-30-9 6-(4-methoxyphenyl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purine 

Downstream Products

• 1316308-67-4 9-[(Z)-4'-chloro-2'-buten-1'-yl]-6-(4-methoxyphenyl)purine 
• 1316308-69-6 9-[(E)-4'-chloro-2'-buten-1'-yl]-6-(4-methoxyphenyl)purine 
• 1316308-71-0 9-[(Z)-4'-chloro-2'-butyn-1'-yl]-6-(4-methoxyphenyl)purine 
• 328378-39-8 9-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-6-(4-methoxyphenyl)purine 

Relevant articles and documents

Synthesis and cytotoxic activity of some new 2,6-substituted purines

A seriesof twenty four acyclic unsaturated 2,6-substututed purines 5a-20b were synthesized. These compounds were evaluated for cytotoxic activity against NCI-60 DTP human tumor cell line screen at 10?Mconcentration. N 9-[(Z)-4′-chloro-2′-butenyl-1′-yl]-2, 6-dichloropurine(5a), N9-[4′-chloro-2′-butynyl-1′- yl]-2,6-dichloropurine(10a), N9-[(E)-2′,3′-dibromo- 4′-chloro-2′-butenyl-1′-yl]-6-methoxypurine(14)and N 9-[4′-chloro-2′-butynyl-1′-yl]-6-(4-methoxyphenyl) -purine(19)exhibited highly potent cytotoxic activity with GI50 values in the 1-5 μM range for most human tumor cell lines. Other compounds exhibited moderate activity.

Cytostatic 6-arylpurine nucleosides II. Synthesis of sugar-modified derivatives: 9-(2-deoxy-β-D-erythro-pentofuranosyl)-, 9-(5-deoxy-β-D-ribofuranosyl)- and 9-(2,3-dihydroxypropyl)-6-phenylpurines

9-(2-Deoxy-β-D-erythro-pentofuranosyl)-6-(4-substituted phenyl)purines, 9-(5-deoxy-β-D-ribofuranosyl)-6-(4-substituted phenyl)purines and 9-(2,3-dihydroxypropyl)-6-(4-substituted phenyl)purines were prepared by the Suzuki-Miyaura cross-coupling reactions of the corresponding protected 9-substituted 6-chloropurines with substituted phenylboronic acids followed by MeONa mediated deprotection. In contrast to the highly active 6-phenylpurine ribonucleosides, the title compounds did not show any considerable cytostatic activity.