32863-30-2

Basic information

• Product Name: 4-(BROMOMETHYL)-2,1,3-BENZOXADIAZOLE
• Synonyms: 4-(BROMOMETHYL)-2,1,3-BENZOXADIAZOLE;4-(bromomethyl)benzo[c][1,2,5]oxadiazole
• CAS NO: 32863-30-2
• Molecular Formula: C₇H₅BrN₂O
• Molecular Weight: 213.03
• Mol File: 32863-30-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 77 °C
• Boiling Point: 283.5℃
• Flash Point: 125.3℃
• Appearance: /
• Density: 1.742
• Vapor Pressure: 0.00538mmHg at 25°C
• Refractive Index: 1.661
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.31±0.45(Predicted)
• CAS DataBase Reference: 4-(BROMOMETHYL)-2,1,3-BENZOXADIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(BROMOMETHYL)-2,1,3-BENZOXADIAZOLE(32863-30-2)
• EPA Substance Registry System: 4-(BROMOMETHYL)-2,1,3-BENZOXADIAZOLE(32863-30-2)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 26-37/39
• Hazardous Substances Data: 32863-30-2(Hazardous Substances Data)

Usage

General Description

4-(Bromomethyl)-2,1,3-benzoxadiazole is a chemical compound with the molecular formula C8H6BrN3O. It is a benzoxadiazole derivative that contains a bromomethyl substituent. 4-(BROMOMETHYL)-2,1,3-BENZOXADIAZOLE is primarily used as a building block in the synthesis of various organic compounds and materials. It is also used in research and development for the design of new drugs and pharmaceuticals. 4-(Bromomethyl)-2,1,3-benzoxadiazole is a highly reactive compound and should be handled with care due to its potential health hazards and environmental risks. It is important to use proper safety precautions and handling procedures when working with this chemical.

InChI:InChI=1/C7H5BrN2O/c8-4-5-2-1-3-6-7(5)10-11-9-6/h1-3H,4H2

Upstream product

• 4887-83-6 4-methylbenzimidazole 
• 16714-18-4 2-methyl-6-nitroazidobenzene 
• 3523-86-2 4-methylbenzofurazan oxide 
• 29091-40-5 4-methyl-benzo[1,2,5]oxadiazole 

Downstream Products

• 32863-32-4 benzo[c][1,2,5]oxadiazole-4-carbaldehyde 
• 175609-19-5 4-hydroxymethylbenzofurazan 
• 72803-02-2 darodipine 
• 102993-40-8 2-acetyl-3-benzofurazan-4-yl-acrylic acid methyl ester 

Relevant articles and documents

Biphenyl compound as well as preparation method and medical application thereof

The invention discloses a biphenyl compound as well as a preparation method and medical application thereof, the structure of the biphenyl compound is shown as a formula (I) or a formula (II), and thebiphenyl compound or pharmaceutically acceptable salt, tautomer, meso-isomer, raceme, stereoisomer, metabolite, metabolite precursor, prodrug or solvate thereof is a PD-L1 inhibitor. The compound hasa remarkable inhibiting effect on the interaction of PD-1 and PD-L1 protein, so that the compound can be applied to the preparation of PD-L1 inhibitors and immunomodulator drugs for preventing or treating tumors, autoimmune diseases, organ transplant rejection, infectious diseases and inflammatory diseases.

Inhibition of nucleoside transport by new analogues of nitrobenzylthioinosine

Nitrobenzylthioinosine (NBTI, 1) was systematically modified by attachment of substituents at positions C6 and N9, and also by substitution of N1 with C. These modifications were chosen to reduce the polarity of the new compounds. Incorporation of the nitro functionality into a benzoxadiazole ring system was considered first. These new nucleosides showed high affinity (1.5-10 nM) towards the nucleoside transport protein as present on human erythrocyte ghosts. Next, modification of this benzoxadiazole ring system with C, S and O in different positions produced a number of less polar nucleosides with affinity in the higher nanomolar range. Modification of N9 was achieved with different alkyl and alcohol substituents. An n-butyl substituent proved best, although all variations yielded substantial decreases in affinity. Replacement of N1 by a carbon atom in combination with a 2-Cl substituent also resulted in a relatively potent NBTI derivative (47 nM).

SYNTHESIS AND INVESTIGATION OF COMPLEX COMPOUNDS OF PALLADIUM WITH α-AMINO ACIDS CONTAINING RESIDUES OF 2,1,3-BENZOTHIA-, 2,1,3-BENZOSELENA-, AND 2,1,3-BENZOXA-DIAZOLES IN THE β POSITION

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