32884-73-4

Basic information

• Product Name: 1H-Indole, 3-[(4-chlorophenyl)thio]-
• CAS NO: 32884-73-4
• Molecular Formula: C14H10ClNS
• Molecular Weight: 259.759
• Mol File: 32884-73-4.mol
• Article Data: 41

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 3-[(4-chlorophenyl)thio]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 3-[(4-chlorophenyl)thio]-(32884-73-4)
• EPA Substance Registry System: 1H-Indole, 3-[(4-chlorophenyl)thio]-(32884-73-4)

Safety Data

• Hazardous Substances Data: 32884-73-4(Hazardous Substances Data)

Upstream product

• 496-15-1 1-indoline 
• 106-54-7 p-Chlorothiophenol 
• 1466-88-2 2-nitrocinnamic aldehyde 
• 120-72-9 indole 
• 13165-81-6 ethyl p-chlorobenzenesulphinate 
• 106-46-7 para-dichlorobenzene 
• 637-87-6 1-Chloro-4-iodobenzene 
• 17356-08-0 thiourea 
• 64605-23-8 2'-amino-2-chloroacetophenone 
• 50695-53-9 N-(p-chlorobenzenesulfonyl)hydroxylamine 
• 30384-54-4 sodium S-(4-chlorophenyl) thiosulfate 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 100-03-8 4-chlorobenzenesulfinic acid 
• 2751-25-9 p-chlorophenylsulfonyl hydrazide 

Downstream Products

• 139493-28-0 2-<(4-chlorophenyl)thio>indole 

Relevant articles and documents

Flavin/I2-Catalyzed Aerobic Oxidative C–H Sulfenylation of Aryl-Fused Cyclic Amines

We report an aerobic oxidative C–H sulfenylation of aryl-fused cyclic amines with various thiols catalyzed by flavin/I2 for the first time. While flavin I catalyzed the C–H sulfenylation of indolines to afford 3-sulfenylindoles, flavin II enabl

Cuprous complex, preparation method thereof and application of cuprous complex in synthesis of 3-indolyl thioether

The invention relates to a cuprous complex, a preparation method thereof and an application of the cuprous complex in synthesis of 3-indolyl thioether. The structural formula of the cuprous complex isshown in the specification, Ar is aryl containing a benzene ring or heterocyclic aryl, and ''.'' is a boron hydrogen bond; the preparation method comprises the following steps: 1) dissolving ortho-carborane diformaldehyde and arylamine in an organic solvent, reacting at 60-100 DEG C, and cooling to room temperature after the reaction is finished; and 2) adding CuI, reacting at room temperature for 3-6 hours, and separating to obtain the cuprous complex. Compared with the prior art, the cuprous complex containing the ortho-position carborane Schiff base ligand can efficiently catalyze the coupling reaction of synthesizing a 3-indolyl thioether compound from indole and thiophenol, the method has the advantages of high selectivity, low catalyst dosage, mild reaction conditions, open reaction(taking air as an oxidant), high reaction rate, high yield, wide substrate range and the like and shows a wide industrial application prospect.

Domino C?S/C?N Bond Formation Using Well-Defined Copper-Phosphine Complex Catalyst: Divergent Approach to 3-Sulfenylated Indoles

A protocol was developed for the synthesis of 3-thioindoles in good-to-excellent yields involving sulfenylation between 2-nitrocinnamaldehydes and various thiols using a well-defined copper(I)-phosphine complex catalyst. This unconventional divergent approach involves in situ generation of indoles via domino C?S/C?N bond formation initiated by sulfa-Michael addition followed by intramolecular N-heteroannulation. This protocol shows good chemoselectivity and broad substrate scope. To briefly demonstrate the value of this approach, 2-benzoyl-3-sulfenylated indoles were prepared from commercially available 2-nitrochalcones and thiols. (Figure presented.).