329013-12-9

Basic information

• Product Name: BOC-(R)-3-AMINO-3-(4-HYDROXY-PHENYL)-PROPIONIC ACID
• Synonyms: RARECHEM DK TW 0163;(R)-3-TERT-BUTOXYCARBONYLAMINO-3-(4-HYDROXY-PHENYL)-PROPIONIC ACID;(R)-3-T-BUTOXYCARBONYL-AMINO-3-(4-HYDROXY-PHENYL)-PROPIONIC ACID;N-BETA-T-BUTOXYCARBONYL-BETA-L-HOMO(4-HYDROXYPHENYL)GLYCINE;BOC-(R)-3-AMINO-3-(4-HYDROXY-PHENYL)-PROPANOIC ACID;BOC-(R)-3-AMINO-3-(4-HYDROXY-PHENYL)-PROPIONIC ACID;BOC-PHG(4-OH)-(C*CH2)OH;BOC-D-BETA-PHE(4-OH)-OH
• CAS NO: 329013-12-9
• Molecular Formula: C₁₄H₁₉NO₅
• Molecular Weight: 281.3
• Product Categories: 3-Amino-3-phenylpropanoic Acid Analogs;B-Amino
• Mol File: 329013-12-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 476.7 °C at 760 mmHg
• Flash Point: 242.1 °C
• Appearance: /
• Density: 1.236g/cm³
• Vapor Pressure: 6.78E-10mmHg at 25°C
• Refractive Index: 1.549
• Storage Temp.: 2-8°C
• PKA: 4.41±0.10(Predicted)
• CAS DataBase Reference: BOC-(R)-3-AMINO-3-(4-HYDROXY-PHENYL)-PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-(R)-3-AMINO-3-(4-HYDROXY-PHENYL)-PROPIONIC ACID(329013-12-9)
• EPA Substance Registry System: BOC-(R)-3-AMINO-3-(4-HYDROXY-PHENYL)-PROPIONIC ACID(329013-12-9)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 329013-12-9(Hazardous Substances Data)

Usage

General Description

BOC-(R)-3-Amino-3-(4-hydroxy-phenyl)-propionic acid is a precise chemical used primarily in the realm of organic chemistry. It contains a variety of functional groups that comprise a BOC group, an amino group, a carboxylic acid and a phenyl group linked to a hydroxy group. This complex chemical compound exhibits chirality meaning it has an important spatial arrangement of its molecules. This is because of the presence of an asymmetrical carbon atom, therefore existing as enantiomers (non-superimposable mirror images). BOC is often used in chemical synthesis to protect the amino group. BOC-(R)-3-AMINO-3-(4-HYDROXY-PHENYL)-PROPIONIC ACID can play crucial roles in scientific research and pharmaceutical development. However, information regarding its specific uses is not readily available and would require further research or consultation with chemical experts.

InChI:InChI=1/C14H19NO5/c1-14(2,3)20-13(19)15-11(8-12(17)18)9-4-6-10(16)7-5-9/h4-7,11,16H,8H2,1-3H3,(H,15,19)(H,17,18)

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 499995-80-1 C₁₄H₁₉NO₅ 
• 329013-03-8 3-(4-hydroxy-phenyl)-3-phenylacetylamino-propionic acid 
• 6049-54-3 3-amino-3-(4-hydroxyphenyl)propionic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 73025-68-0 (R)-3-amino-3-(4-hydroxyphenyl)propanoic acid 

Downstream Products

• 73025-68-0 (R)-3-amino-3-(4-hydroxyphenyl)propanoic acid 
• 1218781-44-2 C₁₇H₂₆N₂O₄ 
• 1218781-47-5 C₃₃H₅₃N₅O₆ 
• 1218781-43-1 C₂₂H₃₄N₂O₆ 
• 131791-82-7 methyl (-)-(3R)-3-amino-3-(4-methoxyphenyl)propanoate 

Relevant articles and documents

Resolution synthesis method of 3-amino-3-(4-hydroxyphenyl)propionic acid

The invention relates to a resolution synthesis method of 3-amino-3-(4-hydroxyphenyl)propionic acid, mainly aiming at solving the technical problems of an existing synthesis method of more steps and high cost. The resolution synthesis method comprises the following steps: enabling p-hydroxybenzaldehyde to react with ammonium acetate and malonic acid in an ethanol solution to generate a compound 1; enabling the compound 1 to react with triethylamine and di-tert-butyl dicarbonate in a mixed solution of water and acetone to generate a compound 2; enabling the compound 2 to react with R(+)-1-phenethylamine in a tetrahydrofuran solution; acidifying an intermediate product with hydrochloric acid to generate a compound 3; enabling the compound 3 to react with an ethanol solution of hydrochloric acid to obtain hydrochloride, and enabling the hydrochloride to react with a sodium hydroxide water solution to obtain a target compound 4; enabling the compound 2 to react with S-1-phenethylamine in the tetrahydrofuran solution, and acidifying an intermediate product with the hydrochloric acid to generate a compound 5; enabling the compound 5 to react with the ethanol solution of the hydrochloric acid to obtain hydrochloride and enabling the hydrochloride to react with a sodium hydroxide water solution to obtain a target compound 6. (R)- and (S)-3-amino-3-(4-hydroxyphenyl)propionic acid is widely applied in a polypeptide biopharmaceutical industry.