329025-44-7Relevant articles and documents
Tuning photophysical properties of triphenylamine and aromatic cyano conjugate-based wavelength-shifting compounds by manipulating intramolecular charge transfer strength
Li, Yilin,Ren, Tianhui,Dong, Wen-Ji
, p. 1 - 9 (2013)
A series of triphenylamine-based aromatic cyano compounds have been synthesized as red-emitting fluorophores with large Stokes shifts in both solution (>100 nm in CHCl3) and solid state (>150 nm in film). Intramolecular charge transfer (ICT) properties of the synthesized compounds are examined using UV-Vis absorptions, photoluminescence measurements and solvatochromic studies. Our studies suggest that Stokes shifts of these compounds can be fine-tuned by manipulating the ICT strength between donor and acceptor with various electronic donating groups, and the largest Stokes shifts are typically associated with compounds that have the strong ICT characters. The observed spectroscopic properties of the compounds are consistent with theoretical calculations using density function theory (DFT) or time-dependent density function theory (TD-DFT). The calculations suggest that the ICT occurs from localized HOMO to localized LUMO with magnitudes of 60-80%. The relative quantum yields of these fluorophores in solution are various and highly solvent dependent. In solid state, the quantum yields of the compounds are significantly increased and some can reach to 0.40.
Three-Pronged Attack by Homologous Far-red/NIR AIEgens to Achieve 1+1+1>3 Synergistic Enhanced Photodynamic Therapy
Kwok, Ryan T. K.,Lam, Jacky W. Y.,Lee, Michelle M. S.,Nie, Jing-Jun,Tang, Ben Zhong,Wang, Dong,Xu, Fu-Jian,Xu, Wenhan,Zhang, Zhihan
, p. 9610 - 9616 (2020)
Photodynamic therapy (PDT) has long been shown to be a powerful therapeutic modality for cancer. However, PDT is undiversified and has become stereotyped in recent years. Exploration of distinctive PDT methods is thus highly in demand but remains a severe challenge. Herein, an unprecedented 1+1+1>3 synergistic strategy is proposed and validated for the first time. Three homologous luminogens with aggregation-induced emission (AIE) characteristics were rationally designed based on a simple backbone. Through slight structural tuning, these far-red/near-infrared AIE luminogens are capable of specifically anchoring to mitochondria, cell membrane, and lysosome, and effectively generating reactive oxygen species (ROS). Notably, biological studies demonstrated combined usage of three AIE photosensitizers gives multiple ROS sources simultaneously derived from several organelles, which gives superior therapeutic effect than that from a single organelle at the same photosensitizers concentration. This strategy is conceptually and operationally simple, providing an innovative approach and renewed awareness of improving therapeutic effect through three-pronged PDT.
Compound with aggregation-induced emission property as well as preparation method and application thereof
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Paragraph 0068-0071, (2021/06/13)
The invention relates to a compound with aggregation-induced emission property as well as a preparation method and application thereof, the compound has a molecular structural formula, and R1 and R2 are respectively and independently selected from one of H and a group shown as the specification. The compound with the aggregation-induced emission property, provided by the invention, has relatively long absorption and emission wavelengths, the emission wavelength can reach a near-infrared light region, and the compound has efficient I-type ROS generation efficiency. The compound with the aggregation-induced emission property, provided by the invention, can be used for targeting tumor cell nucleus imaging after being wrapped by a cell nucleus targeting carrier to form nanoparticles. Therefore, the material can be used for tumor cell nucleus targeted photodynamic therapy.
Tunable NIR AIE-active optical materials for lipid droplet imaging in typical model organisms and photodynamic therapy
Zhang, Fei,Liu, Yaoming,Yang, Binsheng,Guan, Pengli,Chai, Jie,Wen, Guangming,Liu, Bin
, p. 2417 - 2427 (2021/03/23)
Near infrared (NIR) luminescent materials with aggregation-induced emission (AIE) features have attracted enormous attention in the areas of medical imaging and diagnostic therapeutics because of their low background fluorescence and strong tissue penetra
