32907-43-0

Basic information

• Product Name: Quinazoline, 3-oxide (6CI,7CI,8CI,9CI)
• Synonyms: Quinazoline, 3-oxide (6CI,7CI,8CI,9CI);Quinazoline 3-oxide
• CAS NO: 32907-43-0
• Molecular Formula: C₈H₆N₂O
• Molecular Weight: 0
• Product Categories: PYRIMIDINE
• Mol File: 32907-43-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 343.9°Cat760mmHg
• Flash Point: 161.8°C
• Appearance: /
• Density: 1.24g/cm³
• Vapor Pressure: 0.000136mmHg at 25°C
• Refractive Index: 1.64
• CAS DataBase Reference: Quinazoline, 3-oxide (6CI,7CI,8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Quinazoline, 3-oxide (6CI,7CI,8CI,9CI)(32907-43-0)
• EPA Substance Registry System: Quinazoline, 3-oxide (6CI,7CI,8CI,9CI)(32907-43-0)

Safety Data

• Hazardous Substances Data: 32907-43-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H6N2O/c11-10-5-7-3-1-2-4-8(7)9-6-10/h1-6H

Upstream product

• 3398-07-0 2-aminobenzaldehyde oxime 
• 122-51-0 orthoformic acid triethyl ester 
• 149-73-5 trimethyl orthoformate 
• 5344-90-1 2-Aminobenzyl alcohol 
• 253-82-7 quinazoline 

Downstream Products

• 7152-38-7 4-Hydroxy-chinazolin-3-oxid 
• 20873-06-7 benzoic acid 4-oxo-4H-quinazolin-3-yl ester 
• 1620004-04-7 N-(2-(4-(2-bromo-4,5-dimethoxyphenyl)-5-oxa-6-azaspiro[2.4]hept-6-en-7-yl)phenyl)formamide 
• 1620004-03-6 N-(2-(4-(4-fluorophenyl)-5-oxa-6-azaspiro[2.4]hept-6-en-7-yl)phenyl)formamide 
• 1620004-02-5 N-(2-(4-(4-bromophenyl)-5-oxa-6-azaspiro[2.4]hept-6-en-7-yl)phenyl)formamide 
• 1620004-01-4 N-(2-(4-(4-methoxyphenyl)-5-oxa-6-azaspiro[2.4]hept-6-en-7-yl)phenyl)formamide 
• 1620004-00-3 N-(2-(4-(2-chlorophenyl)-5-oxa-6-azaspiro[2.4]hept-6-en-7-yl)phenyl)formamide 
• 1620003-99-7 N-(2-(4-phenyl-5-oxa-6-azaspiro[2.4]hept-6-en-7-yl)phenyl)formamide 
• 1904-65-0 1,2,3,4-tetrahydroquinazoline 

Relevant articles and documents

A Biocatalytic Synthesis of Heteroaromatic N-Oxides by Whole Cells of Escherichia coli Expressing the Multicomponent, Soluble Di-Iron Monooxygenase (SDIMO) PmlABCDEF

Aromatic N-oxides (ArN?OX) are desirable biologically active compounds with a potential for application in pharmacy and agriculture industries. As biocatalysis is making a great impact in organic synthesis, there is still a lack of efficient and convenient enzyme-based techniques for the production of aromatic N-oxides. In this study, a recombinant soluble di-iron monooxygenase (SDIMO) PmlABCDEF overexpressed in Escherichia coli was showed to produce various aromatic N-oxides. Out of 98 tested N-heterocycles, seventy were converted to the corresponding N-oxides without any side oxidation products. This whole-cell biocatalyst showed a high activity towards pyridines, pyrazines, and pyrimidines. It was also capable of oxidizing bulky N-heterocycles with two or even three aromatic rings. Being entirely biocatalytic, our approach provides an environmentally friendly and mild method for the production of aromatic N-oxides avoiding the use of strong oxidants, organometallic catalysts, undesirable solvents, or other environment unfriendly reagents. (Figure presented.).